Dehghani Mansooreh, Keshtgar Laila, Javaheri Mohammad Reza, Derakhshan Zahra, Oliveri Conti Gea, Zuccarello Pietro, Ferrante Margherita
Research Center for Health Sciences, Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Environmental Science and Technology Research Center, Department of Environmental Health Engineering, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mol Med Rep. 2017 May;15(5):3390-3397. doi: 10.3892/mmr.2017.6387. Epub 2017 Mar 24.
World Health Organization classifies air pollution as the first cause of human cancer. The present study investigated impact of air pollutants on the mortality rates of lung cancer and leukemia in Shiraz, one of the largests cities of Iran. This cross‑sectional (longitudinal) study was carried out in Shiraz. Data on six main pollutants, CO, SO2, O3, NO2, PM10 and PM2.5, were collected from Fars Environmental Protection Agency for 3,001 days starting from 1 January, 2005. Also, measures of climatic factors (temperature, humidity, and air pressure) were obtained from Shiraz Meteorological Organization. Finally, data related to number of deaths due to lung and blood cancers (leukemia) were gathered from Shiraz University Hospital. Relationship between variations of pollutant concentrations and cancers in lung and blood was investigated using statistical software R and MiniTab to perform time series analysis. Results of the present study revealed that the mortality rate of leukemia had a direct significant correlation with concentrations of nitrogen dioxide and carbon monoxide in the air (P<0.05). Therefore, special attention should be paid to sources of these pollutants and we need better management to decrease air pollutant concentrations through, e.g., using clean energy respect to fossil fuels, better management of urban traffic planning, and the improvement of public transport service and car sharing.
世界卫生组织将空气污染列为人类癌症的首要成因。本研究调查了空气污染物对伊朗最大城市之一设拉子肺癌和白血病死亡率的影响。这项横断面（纵向）研究在设拉子开展。从2005年1月1日起的3001天里，从法尔斯环境保护局收集了六种主要污染物（一氧化碳、二氧化硫、臭氧、二氧化氮、可吸入颗粒物和细颗粒物）的数据。此外，气候因素（温度、湿度和气压）的测量数据来自设拉子气象组织。最后，从设拉子大学医院收集了与肺癌和血癌（白血病）死亡人数相关的数据。使用统计软件R和Minitab进行时间序列分析，研究污染物浓度变化与肺癌和血癌之间的关系。本研究结果显示，白血病死亡率与空气中二氧化氮和一氧化碳浓度呈直接显著相关（P<0.05）。因此，应特别关注这些污染物的来源，我们需要通过例如使用清洁能源替代化石燃料、更好地管理城市交通规划以及改善公共交通服务和拼车等方式，来更好地管理以降低空气污染物浓度。
