Cecil Todd L, Brewer Tim M, Young Mimy, Holman Matthew R
Office of Science, Center for Tobacco Products, United States Food and Drug Administration, Silver Spring, MD.
Nicotine Tob Res. 2017 Jul 1;19(7):865-870. doi: 10.1093/ntr/ntx003.
Many carbonyls are produced from the combustion of tobacco products and many of these carbonyls are harmful or potentially harmful constituents of mainstream cigarette smoke. One carbonyl of particular interest is acrolein, which is formed from the incomplete combustion of organic matter and the most significant contributor to non-cancer respiratory effects from cigarette smoke. Sheet-wrapped cigars, also known as "little cigars," are a type of tobacco products that have not been extensively investigated in literature.
This study uses standard cigarette testing protocols to determine the acrolein yields from sheet-wrapped cigars. Sheet-wrapped cigar and cigarette products were tested by derivatizing the mainstream smoke with 2,4-dinitrophenylhydrazine (DNPH) solution and then quantifying the derivatives using conventional analytical systems.
The results demonstrate that sheet-wrapped cigars can be tested for acrolein yields in mainstream smoke using the same methods used for the evaluation of cigarettes. The variability in the sheet-wrapped cigars and cigarettes under the International Organization for Standardization smoking regimen is statistically similar at the 95% confidence interval; however, increased variability is observed for sheet-wrapped cigar products under the Health Canada Intense (CI) smoking regimen.
The amount of acrolein released by smoking sheet-wrapped cigars can be measured using standard smoking regimen currently used for cigarettes. The sheet-wrapped cigars were determined to yield similar quantity of acrolein from commercial cigarette products using two standard smoking regimens.
This article reports on the measured quantity of acrolein from 15 commercial sheet-wrapped cigars using a validated standard smoking test method that derivatizes acrolein in the mainstream smoke with DNPH solution, and uses Liquid Chromatography/Ultra-Violet Detection (LC/UV) for separation and detection. These acrolein yields were similar to the levels found in the smoke from 35 commercial cigarette products measured in the same manner. Although sheet-wrapped cigar data were slightly more variable than those found for the cigarette data, this article reports that the production of acrolein is similar to cigarettes. The results demonstrate that sheet-wrapped cigars can be tested for acrolein yields in mainstream smoke using the same methods used for the evaluation of cigarettes.
烟草制品燃烧会产生多种羰基化合物，其中许多是主流卷烟烟气中的有害或潜在有害成分。一种特别受关注的羰基化合物是丙烯醛，它由有机物不完全燃烧形成，是卷烟烟气中非致癌性呼吸道影响的最主要贡献者。薄片包装雪茄，也称为“小雪茄”，是一类在文献中未得到广泛研究的烟草制品。
本研究采用标准卷烟测试方案来测定薄片包装雪茄的丙烯醛释放量。通过用2,4-二硝基苯肼（DNPH）溶液对主流烟气进行衍生化，然后使用传统分析系统对衍生物进行定量，对薄片包装雪茄和卷烟产品进行测试。
结果表明，可使用与评估卷烟相同的方法来测试薄片包装雪茄主流烟气中的丙烯醛释放量。在国际标准化组织吸烟方案下，薄片包装雪茄和卷烟的变异性在95%置信区间内具有统计学相似性；然而，在加拿大卫生部强化（CI）吸烟方案下，薄片包装雪茄产品的变异性有所增加。
使用目前用于卷烟的标准吸烟方案可以测量吸食薄片包装雪茄释放的丙烯醛量。通过两种标准吸烟方案确定，薄片包装雪茄产生的丙烯醛量与商业卷烟产品相似。
本文报告了使用经过验证的标准吸烟测试方法，对15种商业薄片包装雪茄中的丙烯醛测量量。该方法用DNPH溶液对主流烟气中的丙烯醛进行衍生化，并使用液相色谱/紫外检测（LC/UV）进行分离和检测。这些丙烯醛释放量与以相同方式测量的35种商业卷烟产品烟气中的水平相似。尽管薄片包装雪茄的数据比卷烟数据的变异性略大，但本文报告称丙烯醛的产生与卷烟相似。结果表明，可使用与评估卷烟相同的方法来测试薄片包装雪茄主流烟气中的丙烯醛释放量。
