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大雪茄:吸烟形态与毒物暴露。

Large Cigars: Smoking Topography and Toxicant Exposure.

机构信息

Battelle Public Health Center for Tobacco Research, Baltimore, MD.

出版信息

Nicotine Tob Res. 2018 Jan 5;20(2):183-191. doi: 10.1093/ntr/ntw289.

Abstract

BACKGROUND

Cigar smoking in the United States continues despite decreases in cigarette smoking and increased tobacco control efforts. We compared large cigar and cigarette smoking for use patterns, smoking topography, and toxicant exposure.

METHODS

Dual users (n = 17, 94% men, 77% African American) smoked ad libitum either their usual cigarette brand or a study large cigar (Phillies Blunt) in two laboratory sessions. Plasma nicotine and exhaled carbon monoxide were collected before and after smoking. Smoking topography measures of puff volume, puff duration, puff velocity, and interpuff interval were also collected.

RESULTS

Both cigarettes and large cigars significantly increased plasma nicotine and carbon monoxide and significantly decreased the urge to smoke. Cigarettes delivered more nicotine per gram of tobacco smoked and per 1000 mL of puff volume. Number of puffs, time to smoke, puff volume, and puff velocity were significantly larger and interpuff interval was significantly shorter in large cigar smoking. The temporal pattern of puffing more intensely at the beginning of smoking was similar for both large cigars and cigarettes.

CONCLUSIONS

People who regularly use both large cigars and cigarettes adapt their smoking pattern such that they are exposed to similar levels of nicotine from each product. The immediate increase in plasma nicotine and carbon monoxide suggest significant inhalation of large cigar smoke. These data call to question the assumption that cigar smoking is less toxic than cigarette smoking. By smoking large cigars, dual users expose themselves to toxic components that have been linked with the addiction risk, morbidity, and mortality of cigarette smoking.

IMPLICATIONS

This study found that dual users of large cigars and cigarettes inhale significant quantities of carbon monoxide, nicotine, and presumably other components of mainstream smoke. Large cigar smoke exposure may lead to or sustain nicotine addiction as wells as subject large cigar consumers to similar risks associated with cigarette smoking such as lung cancer and cardiovascular disease.

摘要

背景

尽管美国的香烟吸烟量有所减少,且烟草控制力度有所加大,但雪茄烟的吸烟量仍在继续。我们比较了大雪茄和香烟的使用模式、吸烟特征和有毒物质暴露情况。

方法

双用户(n = 17,94%为男性,77%为非裔美国人)在两次实验室吸烟中,随意吸烟他们通常的香烟品牌或研究用大雪茄(Phil ies Blunt)。吸烟前和吸烟后收集血浆尼古丁和呼出的一氧化碳。还收集了吸烟特征的测量值,包括吸气量、吸气流速、吸气流速和吸间间隔。

结果

香烟和大雪茄都显著增加了血浆尼古丁和一氧化碳,并显著降低了吸烟的欲望。每克烟草吸烟和每 1000 毫升吸气量中,香烟输送的尼古丁更多。吸雪茄的次数、吸烟时间、吸气量和吸气流速都明显较大,吸间间隔明显较短。在开始吸烟时更强烈地吸的时间模式对于大雪茄和香烟来说是相似的。

结论

经常同时使用大雪茄和香烟的人会调整他们的吸烟方式,使他们从每种产品中摄入相似水平的尼古丁。血浆尼古丁和一氧化碳的立即增加表明大量吸入了大雪茄烟。这些数据对雪茄烟比香烟毒性小的假设提出了质疑。通过吸食大雪茄,双重使用者暴露于与吸烟成瘾风险、发病率和死亡率相关的有毒成分中。

意义

本研究发现,吸食大雪茄和香烟的双重使用者吸入了大量的一氧化碳、尼古丁和可能的其他主流烟雾成分。大雪茄烟雾暴露可能导致或维持尼古丁成瘾,并使大雪茄消费者面临与吸烟相关的类似风险,如肺癌和心血管疾病。

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