Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Institute of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Poult Sci. 2017 Jul 1;96(7):2104-2109. doi: 10.3382/ps/pew499.
In this study, coccidia were isolated and identified from 5 main poultry farms located in Zhejiang province, eastern China. The overall prevalence of Eimeria spp. was 30.7% (95 of 310). Five common species were observed: E. tenella, E. acervulina, E. maxima, E. necatrix, and E. mitis. Two isolates (HZ and QZ) were tested for sensitivity to 8 anticoccidial drugs using 4 indexes including anticoccidial index (ACI), percent of optimum anticoccidial activity (POAA), reduction of lesion scores (RLS), and relative oocyst production (ROP): sulfachloropyrazine, toltrazuril, diclazuril, sulfamonomethoxine/trimethoprim, and amprolium; sulfaquinoxaline/sulfadimethoxine, nicarbazin, and halofuginone. The results showed that the 2 isolates have developed various degrees of resistance to most of the tested drugs. The multi-resistance coccidia are a potential threat to local poultry farming. Rotation of anticoccidial drugs and shuttle programs are recommended to prevent further economic losses caused by coccidiosis.
在这项研究中，从位于中国东部浙江省的 5 个主要家禽养殖场中分离和鉴定了球虫。艾美耳球虫属的总流行率为 30.7%（310 例中的 95 例）。观察到 5 种常见种：柔嫩艾美耳球虫、毒害艾美耳球虫、巨型艾美耳球虫、堆型艾美耳球虫和缓艾美耳球虫。对 2 个分离株（HZ 和 QZ）进行了 8 种抗球虫药物敏感性测试，使用包括抗球虫指数（ACI）、最佳抗球虫活性百分比（POAA）、病变评分降低（RLS）和相对卵囊产量（ROP）在内的 4 个指标：磺胺氯吡嗪、托曲珠利、地克珠利、磺胺二甲氧嘧啶/甲氧苄啶和氨丙啉；磺胺喹噁啉/磺胺二甲氧嘧啶、尼卡巴嗪和常山酮。结果表明，这 2 个分离株对大多数测试药物产生了不同程度的耐药性。多耐药球虫对当地家禽养殖业构成了潜在威胁。建议轮换使用抗球虫药物和穿梭方案，以防止球虫病造成的进一步经济损失。
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