Romagnoli Katrina M, Boyce Richard D, Empey Philip E, Ning Yifan, Adams Solomon, Hochheiser Harry
Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
School of Pharmacy, University of Pittsburgh.
J Am Med Inform Assoc. 2017 Jul 1;24(4):822-831. doi: 10.1093/jamia/ocx007.
To develop and evaluate a pharmacogenomics information resource for pharmacists.
We built a pharmacogenomics information resource presenting Food and Drug Administration (FDA) drug product labelling information, refined it based on feedback from pharmacists, and conducted a comparative usability evaluation, measuring task completion time, task correctness and perceived usability. Tasks involved hypothetical clinical situations requiring interpretation of pharmacogenomics information to determine optimal prescribing for specific patients.
Pharmacists were better able to perform certain tasks using the redesigned resource relative to the Pharmacogenomic Knowledgebase (PharmGKB) and the FDA Table of Pharmacogenomic Biomarkers in Drug Labeling. On average, participants completed tasks in 107.5 s using our resource, compared to 188.9 s using PharmGKB and 240.2 s using the FDA table. Using the System Usability Scale, participants rated our resource 79.62 on average, compared to 53.27 for PharmGKB and 50.77 for the FDA table. Participants found the correct answers for 100% of tasks using our resource, compared to 76.9% using PharmGKB and 69.2% using the FDA table.
We present structured, clinically relevant pharmacogenomic FDA drug product label information with visualizations to help explain the relationships between gene variants, drugs, and phenotypes. The results from our evaluation suggest that user-centered interfaces for pharmacogenomics information can increase ease of access and comprehension.
A clinician-focused pharmacogenomics information resource can answer pharmacogenomics-related medication questions faster, more correctly, and more easily than widely used alternatives, as perceived by pharmacists.
开发并评估一个面向药剂师的药物基因组学信息资源。
我们构建了一个展示美国食品药品监督管理局（FDA）药品标签信息的药物基因组学信息资源，根据药剂师的反馈对其进行完善，并开展了一项比较可用性评估，测量任务完成时间、任务正确性和感知可用性。任务涉及假设的临床情况，需要解读药物基因组学信息以确定特定患者的最佳处方。
相对于药物基因组知识库（PharmGKB）和FDA药品标签中的药物基因组生物标志物表格，药剂师使用重新设计的资源能更好地完成某些任务。平均而言，参与者使用我们的资源完成任务用时107.5秒，而使用PharmGKB用时188.9秒，使用FDA表格用时240.2秒。使用系统可用性量表，参与者对我们资源的平均评分为79.62，而对PharmGKB的评分为53.27，对FDA表格的评分为50.77。使用我们的资源，参与者100%找到了任务的正确答案，而使用PharmGKB的正确率为76.9%，使用FDA表格的正确率为69.2%。
我们展示了结构化的、与临床相关的FDA药品标签药物基因组学信息，并配有可视化内容以帮助解释基因变异、药物和表型之间的关系。我们的评估结果表明，以用户为中心的药物基因组学信息界面可以提高获取和理解的便利性。
药剂师认为，与广泛使用的其他资源相比，以临床医生为重点的药物基因组学信息资源能够更快、更准确、更轻松地回答与药物基因组学相关的用药问题。
