College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling, China.
College of Life Science, Northwest A&F University, Yangling, China.
Cell Prolif. 2021 Feb;54(2):e12970. doi: 10.1111/cpr.12970. Epub 2020 Dec 17.
Complex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three-dimensional structure of the genome, plays an important role in gene regulation and expression. The super enhancers are important for defining cell identity in mammalian developmental processes and human diseases. It has been shown that the major components of transcriptional activation complexes are recruited by super enhancer to form phase-separated condensates. We summarize the current knowledge about super enhancer in the 3D genome. Furthermore, a new related transcriptional regulation model from super enhancer is outlined to explain its role in the mammalian cell progress.
复杂的生化反应一直在细胞核中进行。转录机器必须遵循规则。染色质状态，特别是基因组的三维结构，在基因调控和表达中起着重要作用。超级增强子在哺乳动物发育过程和人类疾病中定义细胞身份方面非常重要。已经表明，转录激活复合物的主要成分被超级增强子募集形成相分离的凝聚物。我们总结了目前关于 3D 基因组中超增强子的知识。此外，还概述了一个新的与超级增强子相关的转录调控模型，以解释其在哺乳动物细胞进展中的作用。
