Gottschling Daniel E, Nyström Thomas
Calico Life Sciences, South San Francisco, CA 94080, USA.
Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Cell. 2017 Mar 23;169(1):24-34. doi: 10.1016/j.cell.2017.02.030.
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory.
相互连接性和反馈控制是生物系统的标志。这包括细胞器之间的通讯，使它们能够发挥功能并适应不断变化的细胞环境。虽然所有通讯的具体机制仍不明确，但理清细胞器网络的线路对于理解生物系统如何构建以及为何会崩溃（如在衰老过程中发生的那样）至关重要。目前仍缺乏对细胞器间通讯所有途径的全面理解，但重要的主题已开始浮现，主要是在芽殖酵母中。本文将在子系统蛋白质稳态和复杂适应系统理论的背景下对这些途径进行综述。
