筛选可食用植物以检测其可能的抗肿瘤促进活性。

Screening of edible plants against possible anti-tumor promoting activity.

作者信息

Koshimizu K, Ohigashi H, Tokuda H, Kondo A, Yamaguchi K

机构信息

Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.

出版信息

Cancer Lett. 1988 Apr;39(3):247-57. doi: 10.1016/0304-3835(88)90067-5.

DOI:10.1016/0304-3835(88)90067-5

PMID:2834042

Abstract

One hundred twenty-one species of edible plants (133 test-parts) were screened against possible anti-tumor promoting activity by an in vitro short-term assay system of inhibition of Epstein-Barr virus (EBV) activation induced by a phorbol-ester promoter, 12-O-hexadecanoylphorbol-13-acetate (HPA). The methanol-extracts (ME) of 14 species of the edible plants strongly inhibited the activation, 7 moderately and 12 weakly inhibited it. On partition of the randomly selected inactive ME (26 species) with ethyl acetate and water, 13 and 2 species were active, more or less, in the ethyl acetate and water soluble part, respectively. Thus, this result suggested that anti-tumor promoters occur in a wide variety of edible plants. The anti-tumor promoting activity in the crude extracts may be enhanced or reduced with co-occurring factors acting additively, synergistically or antagonistically.

摘要

通过体外短期检测系统，即抑制由佛波酯启动子12 - O - 十六酰佛波醇 - 13 - 乙酸酯（HPA）诱导的爱泼斯坦 - 巴尔病毒（EBV）激活，对121种可食用植物（133个测试部分）进行了可能的抗肿瘤促进活性筛选。14种可食用植物的甲醇提取物（ME）强烈抑制激活，7种中度抑制，12种轻度抑制。在用乙酸乙酯和水对随机选择的无活性ME（26种）进行分配时，分别有13种和2种在乙酸乙酯和水溶性部分或多或少具有活性。因此，该结果表明抗肿瘤促进剂存在于多种可食用植物中。粗提物中的抗肿瘤促进活性可能会因同时存在的因素以相加、协同或拮抗的方式起作用而增强或降低。