Xing Yifei, Chen Tony T, Simmons Walter N, Sankin Georgy, Cocks Franklin H, Lipkin Michael E, Preminger Glenn M, Zhong Pei
1 Department of Mechanical Engineering and Materials Science, Duke University , Durham, North Carolina.
2 School of Medicine, Duke University , Durham, North Carolina.
J Endourol. 2017 May;31(5):502-509. doi: 10.1089/end.2016.0560. Epub 2017 Apr 21.
To investigate the impact of lithotripter focal width on stone fragmentation.
A modified reflector was used to reduce -6 dB beam size of the HM3 lithotripter, while increasing concomitantly peak pressure. Fragmentation in vitro was assessed with modified and original reflectors using BegoStone phantoms. A membrane holder was used to mimic lithotripsy in vivo, and a matrix holder was used to assess variations of fragmentation power in the focal plane of the lithotripter field. Stone fragmentation in vivo produced by the two reflectors was further compared in a swine model.
Stone fragmentation in vitro after 500 (or 2000) shocks was ∼60% (or ∼82%) vs ∼40% (or ∼75%) with original and modified reflector, respectively (p ≤ 0.0016). Fragmentation power with the modified reflector was the highest on the lithotripter axis, but dropped rapidly in the lateral direction and became insignificant at radial distances >6.0 mm. Stone fragmentation with the original reflector was lower along the lithotripter axis, but fragmentation power decayed slowly in lateral direction, with appreciable fragmentation produced at 6.0 mm. Stone fragmentation efficiency in vivo after 500 (or 2000) shocks was ∼70% (or ∼90%) vs ∼45% (or ∼80%) with original and modified reflector, respectively (p ≤ 0.04).
A lithotripter field with broad beam size yields superior stone comminution when compared with narrow beam size under comparable effective acoustic pulse energy both in vivo and in vitro. These findings may facilitate future improvements in lithotripter design to maximize comminution efficiency while minimizing tissue injury.
研究碎石机焦斑宽度对结石破碎的影响。
使用改良反射器减小HM3碎石机的-6dB束斑尺寸,同时相应提高峰值压力。使用BegoStone体模评估改良反射器和原始反射器在体外的破碎情况。使用膜支架模拟体内碎石,使用基质支架评估碎石机焦平面内破碎功率的变化。在猪模型中进一步比较两种反射器在体内产生的结石破碎情况。
在500次(或2000次)冲击后,改良反射器在体外的结石破碎率分别约为60%(或约82%),而原始反射器为约40%(或约75%)(p≤0.0016)。改良反射器的破碎功率在碎石机轴线上最高,但在横向迅速下降,在径向距离>6.0mm时变得不显著。原始反射器沿碎石机轴线的结石破碎率较低,但破碎功率在横向衰减缓慢,在6.0mm处产生明显破碎。在500次(或2000次)冲击后,改良反射器在体内的结石破碎效率分别约为70%(或约90%),而原始反射器为约45%(或约80%)(p≤0.04)。
在体内和体外,在可比的有效声脉冲能量下,与窄束斑尺寸的碎石机场相比,宽束斑尺寸的碎石机场能产生更好的结石粉碎效果。这些发现可能有助于未来改进碎石机设计,以在使组织损伤最小化的同时最大化粉碎效率。