Soke Gnakub N, Maenner M J, Christensen D, Kurzius-Spencer M, Schieve L A
Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention, Atlanta, GA, USA.
National Center on Birth Defects and Developmental Disabilities, Division of Congenital and Developmental Disorders, Developmental Disabilities Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS E-86, Atlanta, GA, 30341, USA.
J Autism Dev Disord. 2017 Jun;47(6):1917-1922. doi: 10.1007/s10803-017-3094-4.
We compared early-diagnosed autism spectrum disorder (ASD) (defined as diagnosis by age 4 years) between the 2002 and 2006 birth cohorts, in five sites of the Autism and Developmental Disabilities Monitoring Network. In the 2002 cohort, the prevalence/1000 of early-diagnosed ASD was half the 8-year-old prevalence (7.2 vs. 14.7, prevalence ratio [PR] 0.5 [0.4-0.6]). Overall, the prevalence of early-diagnosed ASD did not differ between birth cohorts (PR 1.1 [0.9-1.3]). However, in three sites with complete case ascertainment, the prevalence of early-diagnosed ASD was higher for those born in 2006 versus 2002 (PR 1.3 [1.1-1.5]), suggesting possible improvement in early identification. The lack of change in two sites may reflect less complete case ascertainment. Studies in more recent cohorts are needed.
我们在自闭症及发育障碍监测网络的五个地点，对2002年和2006年出生队列中早期诊断的自闭症谱系障碍（ASD）（定义为4岁前确诊）进行了比较。在2002年队列中，早期诊断的ASD患病率/1000是8岁患病率的一半（7.2对14.7，患病率比[PR]0.5[0.4 - 0.6]）。总体而言，出生队列之间早期诊断的ASD患病率没有差异（PR 1.1[0.9 - 1.3]）。然而，在三个病例确诊完整的地点，2006年出生者早期诊断的ASD患病率高于2002年出生者（PR 1.3[1.1 - 1.5]），这表明早期识别可能有所改善。两个地点缺乏变化可能反映了病例确诊不够完整。需要对更近的队列进行研究。
