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女性体内的睾酮:测量与治疗用途

Testosterone in Women: Measurement and Therapeutic Use.

作者信息

Kathryn Korkidakis Ann, Reid Robert L

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON.

出版信息

J Obstet Gynaecol Can. 2017 Mar;39(3):124-130. doi: 10.1016/j.jogc.2017.01.006.

DOI:10.1016/j.jogc.2017.01.006
PMID:28343552
Abstract

Androgens, both in excessive and depleted states, have been implicated in female reproductive health disorders. As such, serum testosterone measurements are frequently ordered by physicians in cases of sexual dysfunction and in women presenting with hirsutism. Commercially available androgen assays have significant limitations in the female population. Furthermore, the measurements themselves are not always informative in patient diagnosis, treatment, or prognosis. This article reviews the limitations of serum androgen measurements in women suspected to have elevated or reduced androgen action. Finally, we consider when therapeutic use of androgen replacement may be appropriate for women with sexual interest/arousal disorders.

摘要

雄激素,无论是处于过量还是缺乏状态,都与女性生殖健康紊乱有关。因此,在性功能障碍病例以及出现多毛症的女性中,医生经常会要求检测血清睾酮水平。市面上现有的雄激素检测方法在女性群体中存在显著局限性。此外,这些检测结果本身在患者的诊断、治疗或预后方面并不总是具有参考价值。本文综述了疑似雄激素作用增强或减弱的女性血清雄激素检测的局限性。最后,我们探讨了雄激素替代疗法何时可能适用于患有性兴趣/性唤起障碍的女性。

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Testosterone in Women: Measurement and Therapeutic Use.女性体内的睾酮:测量与治疗用途
J Obstet Gynaecol Can. 2017 Mar;39(3):124-130. doi: 10.1016/j.jogc.2017.01.006.
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Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women.土耳其女性改良 Ferriman-Gallwey 多毛症评分与雄激素水平。
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Differential studies on the mechanism of serum androgen and androgen-binding abnormalities in hirsutism.多毛症患者血清雄激素及雄激素结合异常机制的差异研究
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To be or not to be in sexual desire: the androgen dilemma.是否存在性欲:雄激素困境。
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Is it necessary to measure free testosterone to assess hyperandrogenemia in women? The role of calculated free and bioavailable testosterone.测量游离睾酮对于评估女性高雄激素血症是否必要?计算游离睾酮和生物可利用睾酮的作用。
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Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part B: Reduced serum androgen levels in healthy premenopausal women with complaints of sexual dysfunction.有和没有性功能障碍的健康绝经前女性的血清雄激素水平:B部分:有性功能障碍主诉的健康绝经前女性血清雄激素水平降低
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[Androgens in the plasma of women with hirsutism (author's transl)].多毛症女性血浆中的雄激素(作者译)
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Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome.外周组织事件在多囊卵巢综合征多毛症发生发展中重要性的证据
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Effect of leuprolide and dexamethasone on hair growth and hormone levels in hirsute women: the relative importance of the ovary and the adrenal in the pathogenesis of hirsutism.亮丙瑞林和地塞米松对多毛症女性毛发生长及激素水平的影响:卵巢和肾上腺在多毛症发病机制中的相对重要性
J Clin Endocrinol Metab. 1990 Apr;70(4):1096-102. doi: 10.1210/jcem-70-4-1096.

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Nutrients. 2021 Apr 2;13(4):1177. doi: 10.3390/nu13041177.
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The prevalence and demographic determinants of blood donors receiving testosterone replacement therapy at a large USA blood service organization.在美国一家大型血库组织中,接受睾丸激素替代疗法的献血者的流行率及其人口统计学决定因素。
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Dehydroepiandrosterone and cortisol as markers of HPA axis dysregulation in women with low sexual desire.
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Psychoneuroendocrinology. 2019 Jun;104:259-268. doi: 10.1016/j.psyneuen.2019.03.001. Epub 2019 Mar 8.