Tejwani Rohit, Young Brian J, Wang Hsin-Hsiao S, Wolf Steven, Purves J Todd, Wiener John S, Routh Jonathan C
Division of Urologic Surgery, Duke University Medical Center, Durham, NC, USA.
Dept of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
J Pediatr Urol. 2017 Jun;13(3):283.e1-283.e9. doi: 10.1016/j.jpurol.2017.01.013. Epub 2017 Feb 22.
Minimally invasive surgery (MIS) techniques are anecdotally reported to be increasingly used, but little objective data supports this. Our objective was to assess trends in MIS utilization across various procedures in pediatric urology and to compare postoperative complication rates between MIS and open procedures.
We analyzed the 1998-2012 Nationwide Inpatient Sample. We identified children (<18 years old) undergoing open and MIS inpatient procedures and any in-hospital post-operative complications that occurred during that postoperative hospitalization. We utilized propensity score matching and multivariable logistic regression to adjust for confounding factors.
We identified 163,838 weighted encounters in the "overall cohort," 70,273 of which were at centers performing more than five MIS procedures over the years studied. Use of MIS techniques increased significantly over time for several procedures, most prominently for nephrectomy (Fig.). The overall rate of complications was lower in patients undergoing MIS compared with open surgery (6% vs. 11%, p < 0.001). Specialized centers had a significantly lower overall rate of complications than unspecialized centers (9% vs. 12%, p < 0.001). Within specialized centers, MIS had lower complication rates than open procedures (7% vs. 9%, p < 0.001); this finding was consistent even after adjusting for other factors (OR 0.71, p = 0.02).
Limitations include that these data may not be generalizable to encounters not in the sample pool. As a large, retrospective, administrative database, NIS may be affected by miscoding bias - rendering our analysis sensitive to the accuracy of procedure coding in NIS. Although the accuracy level of NIS is high for an administrative database, it is possible at least some portion of our cohort may be incorrectly coded. Further, the NSQIP complications we identified may represent associated comorbidities and not true postoperative complications, as NIS does not provide temporal relationships between different diagnosis codes. Despite these limitations, we note that the NIS database is rigorously monitored and audited for coding accuracy and, therefore, represents a reasonably reliable panorama of the characteristics of an inpatient surgical cohort. However, it is important to note that the choice of operative modality is, undoubtedly, multifactorial and patient/setting-specific.
There is increasing use of MIS for pediatric urology procedures, although utilization rates vary among procedures. MIS was associated with a lower postoperative complication rate than for open procedures. Higher-volume MIS centers have a lower complication rate than lower-volume centers.
据传闻,微创手术(MIS)技术的使用越来越多,但客观数据支持不足。我们的目的是评估小儿泌尿外科各种手术中MIS的使用趋势,并比较MIS手术与开放手术的术后并发症发生率。
我们分析了1998 - 2012年全国住院患者样本。我们确定了接受开放手术和MIS住院手术的儿童(<18岁)以及术后住院期间发生的任何院内术后并发症。我们采用倾向评分匹配和多变量逻辑回归来调整混杂因素。
在“总体队列”中,我们确定了163,838次加权就诊,其中70,273次是在研究期间进行超过五次MIS手术的中心。随着时间的推移,几种手术中MIS技术的使用显著增加,最明显的是肾切除术(图)。与开放手术相比,接受MIS手术的患者总体并发症发生率较低(6%对11%,p < 0.001)。专业中心的总体并发症发生率明显低于非专业中心(9%对12%,p < 0.001)。在专业中心内,MIS的并发症发生率低于开放手术(7%对9%,p < 0.001);即使在调整其他因素后,这一发现仍然一致(OR 0.71,p = 0.02)。
局限性包括这些数据可能不适用于样本库之外的就诊情况。作为一个大型的回顾性行政数据库,NIS可能受到编码错误偏差的影响——使我们的分析对NIS中手术编码的准确性敏感。尽管对于行政数据库来说,NIS的准确性水平较高,但至少我们队列中的一部分可能被错误编码。此外,我们确定的NSQIP并发症可能代表相关的合并症,而不是真正的术后并发症,因为NIS没有提供不同诊断代码之间的时间关系。尽管有这些局限性,但我们注意到NIS数据库在编码准确性方面受到严格监测和审核,因此代表了住院手术队列特征的一个相当可靠的全景图。然而,重要的是要注意,手术方式的选择无疑是多因素的,并且因患者/情况而异。
小儿泌尿外科手术中MIS的使用越来越多,尽管不同手术的使用率有所不同。MIS与比开放手术更低的术后并发症发生率相关。高容量MIS中心的并发症发生率低于低容量中心。