Wei Wei, Qi Xiaoliang, Li Junjian, Zhong Yin, Zuo Gancheng, Pan Xihao, Su Ting, Zhang Jianfa, Dong Wei
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Center for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing 210094, China.
Int J Biol Macromol. 2017 Aug;101:474-480. doi: 10.1016/j.ijbiomac.2017.03.106. Epub 2017 Mar 23.
Salecan is a biological macromolecular and biocompatible polysaccharide that has been investigated for recent years. Herein, we report a novel cationic hydrogel fabricated by graft-polymerizing 3-(methacryloylamino)propyl-trimethylammonium chloride (MAPTAC) onto salecan chains. The obtained hydrogels were transparent, solid-elastic, macro-porous, ion-sensitive, and non-cytotoxic. The swelling ratios increased with salecan content, while mechanical strength does the opposite. Moreover, drug delivery test was studied as a potential application. Diclofenac sodium (DS) and insulin were selected as model drugs. Interestingly, in drug loading process, DS molecules exhibited highly affinity to these cationic hydrogels. Almost all the DS molecules in loading solution were absorbed and spread into the hydrogel. For drug release profiles, insulin-loaded hydrogel showed an initial rapid release and a sustained release. As a comparison, DS-loaded hydrogel exhibited a more sustained release profile. Results suggested salecan-g-PMAPTAC hydrogel could be a good candidate for anionic drug loading and delivery.
可得然胶是一种近年来已被研究的生物大分子且具有生物相容性的多糖。在此，我们报道了一种通过将3-(甲基丙烯酰氨基)丙基-三甲基氯化铵（MAPTAC）接枝聚合到可得然胶链上制备的新型阳离子水凝胶。所获得的水凝胶是透明的、具有固体弹性、大孔的、离子敏感的且无细胞毒性。溶胀率随可得然胶含量增加而升高，而机械强度则相反。此外，作为潜在应用对药物递送测试进行了研究。选择双氯芬酸钠（DS）和胰岛素作为模型药物。有趣的是，在载药过程中，DS分子对这些阳离子水凝胶表现出高度亲和力。几乎所有载药溶液中的DS分子都被吸收并扩散到水凝胶中。对于药物释放曲线，载胰岛素水凝胶呈现出初始快速释放和持续释放。作为对比，载DS水凝胶表现出更持续的释放曲线。结果表明可得然胶-g-PMAPTAC水凝胶可能是阴离子药物负载和递送的良好候选材料。
