Turegano Mamina M, Sperling Leonard C
Department of Pathology and Laboratory Medicine, Division of Dermatopathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Maryland.
Department of Dermatology, Uniformed Services University of the Health Sciences, Los Angeles, Maryland.
J Cutan Pathol. 2017 Jul;44(7):647-654. doi: 10.1111/cup.12938. Epub 2017 May 5.
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculatum, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution). An interface dermatitis with lichenoid inflammation is characteristic of the LPP group of disorders, but the literature provides scant information about the histopathology of the KPA group. Our experience has been that the 2 subgroups show a unifying histologic similarity as well as considerable clinical overlap. Because these conditions overlap clinically and histologically, we propose that the term lichenoid folliculitis (LF) be used to refer to this group of diseases, thus simplifying cumbersome nomenclature and highlighting the possibility of shared pathogenesis and treatment options.
表现为角化性丘疹、萎缩、瘢痕性脱发和/或“苔藓样”组织病理学改变的皮肤病已有至少30种命名。这类疾病包含两个亚组,主要基于临床特征划分:萎缩性毛发角化病(KPA;包括面部萎缩性毛发角化病/眉部红斑性萎缩、蠕虫状皮肤萎缩和脱发性棘状毛囊角化病);以及扁平苔藓样毛发扁平苔藓(LPP)亚组(包括LPP、额部纤维性脱发、Graham-Little-Piccardi-Lassueur综合征和扇形分布的纤维性脱发)。界面性皮炎伴苔藓样炎症是LPP组疾病的特征,但文献中关于KPA组组织病理学的信息很少。我们的经验是,这两个亚组在组织学上表现出统一的相似性,临床重叠也很明显。由于这些病症在临床和组织学上存在重叠,我们建议用苔藓样毛囊炎(LF)这一术语来指代这组疾病,从而简化繁琐的命名,并突出共同发病机制和治疗选择的可能性。