Misciagna G, Del Pilar Díaz M, Caramia D V, Bonfiglio C, Franco I, Noviello M R, Chiloiro M, Abbrescia D I, Mirizzi A, Tanzi M, Caruso M G, Correale M, Reddavide R, Inguaggiato R, Cisternino A M, Osella A R
Alberto Rubén Osella, PhD, Laboratory of Epidemiology and Biostatistics, IRCCS Saverio de Bellis, Via Turi 27, 70013 Castellana Grotte (BA), Italy, Tel: +39 0804994655, Fax: +39 0804994650, e-mail:
J Nutr Health Aging. 2017;21(4):404-412. doi: 10.1007/s12603-016-0809-8.
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS).
NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14.
SETTING/PARTICIPANTS: 98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD.
The intervention strategy was the assignment of a LGIMD or a control diet.
The main outcome measure was NAFLD score, defined by LUS.
After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed.
LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.
非酒精性脂肪性肝病（NAFLD）是目前全球最常见的肝脏疾病形式，影响所有年龄段和种族群体，甚至在年轻人中也构成持续威胁。我们的目的是评估低血糖指数地中海饮食（LGIMD）对通过肝脏超声检查（LUS）测量的NAFLD评分的影响。
营养与肝病学（NUTRIEPA）是一项基于人群的双盲随机对照试验。数据于2011年收集，并在2013 - 14年进行分析。
设置/参与者：从之前一项基于人群的随机抽样研究中选取了98名来自普蒂尼亚诺（意大利南部普利亚）的男性和女性，他们被确定患有中度或重度NAFLD。
干预策略是分配LGIMD或对照饮食。
主要观察指标是由LUS定义的NAFLD评分。
随机分组后，50名受试者被分配到LGIMD组，48名被分配到对照饮食组。研究持续了6个月，所有参与者每月接受监测/检查。通过地中海充足指数（MAI）衡量的对LGIMD的依从性中位数为10.1。观察到时间与LGIMD对NAFLD评分存在负向交互作用（-4.14，95%置信区间-6.78，-1.49），在第6个月时更为明显（-4.43，95%置信区间-7.15，-1.71）。还观察到LGIMD、时间和年龄之间的交互作用有正向影响（第3个月：0.07，95%置信区间0.02，0.12；第6个月：0.08，95%置信区间0.03，0.13）。
发现LGIMD在相对较短时间内可降低NAFLD评分。鼓励那些未就医但仍患有NAFLD的受试者遵循LGIMD及其他生活方式干预措施，可能会降低疾病的严重程度。这种饮食干预也可成为2型糖尿病（T2DM）和心血管疾病一级预防的基石。
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