Department of Microbiology, Medicinal Plants Research Center of Barij, Kashan, Iran.
Biomed Pharmacother. 2017 May;89:1422-1430. doi: 10.1016/j.biopha.2017.03.036. Epub 2017 Mar 22.
A. sieberi essential oil has been used for treatment of hardly curable infectious ulcers in Middle East Medicine and has been famous due to its wormicide effects. In this review, we evaluated the potency of A. sieberi essential oil in treatment of fungal infections. We searched in PubMed Central, Science direct, Wiley, Springer, SID, and accessible books, reports, thesis. There is a lot of mixed information on chemical compositions of A. sieberi essential oil, but most articles reported α, β-thujones as the main components of essential oils. In vitro studies confirmed the antifungal activity of A. sieberi essential oil against saprophytes fungi, dermatophytes, Malassezia sp. and Candida sp. and these results were confirmed in six clinical studies. The clinical studies confirmed the superiority of A. sieberi essential oil (5%) lotion in improvement of clinical signs of fungal superficial diseases, and mycological laboratory examinations of dermatophytosis and pityriasis versicolor diseases than clotrimazole (1%) topical treatment. The recurrence rate of superficial fungal infections with dermatophytosis and pityriasis versicolor was statistically lower in A. sieberi essential oil (5%) lotion than clotrimazole. There are no adverse effects due to the application of A. sieberi essential oil in clinical studies. Despite, the efficacy of A. sieberi essential oil against Candida sp., there is no clinical study about their related infections. Investigation about the effects of A. sieberi essential oil on fungal virulence factors in order to identifying the exact mechanism of antifungal activity and clinical trials on Candida related diseases are recommended.
A. sieberi 精油已在中东医学中用于治疗难以治愈的传染性溃疡，并因其驱虫效果而闻名。在本次综述中，我们评估了 A. sieberi 精油治疗真菌感染的功效。我们在 PubMed Central、Science direct、Wiley、Springer、SID 和可获取的书籍、报告、论文中进行了检索。关于 A. sieberi 精油的化学成分有很多混杂的信息，但大多数文章都报道 α、β-侧柏酮是精油的主要成分。体外研究证实了 A. sieberi 精油对腐生性真菌、皮肤癣菌、马拉色菌和念珠菌的抗真菌活性，这一结果在六项临床研究中得到了证实。这些临床研究证实，A. sieberi 精油（5%）洗剂在改善真菌性浅表疾病的临床体征以及皮肤癣菌病和花斑癣的真菌学实验室检查方面优于克霉唑（1%）局部治疗。与克霉唑相比，A. sieberi 精油（5%）洗剂治疗皮肤癣菌病和花斑癣引起的浅表真菌感染的复发率统计学上更低。在临床研究中，由于使用 A. sieberi 精油，没有不良反应。尽管 A. sieberi 精油对念珠菌有效，但目前尚无关于其相关感染的临床研究。建议对 A. sieberi 精油对真菌毒力因子的影响进行调查，以确定其抗真菌活性的确切机制，并开展关于念珠菌相关疾病的临床试验。
