Department of Pharmacognosy, College of Clinical Pharmacy, Baha University, P.O. Box 26553, Taif 3442, Saudi Arabia.
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Molecules. 2023 Nov 7;28(22):7460. doi: 10.3390/molecules28227460.
A phytochemical investigation of the stems of the Arabian plant afforded three new isochlorogenic acid derivatives, namely isochlorogenic acid A-3'---glucopyranoside (), isochlorogenic acid A-3'---glucopyranoside methyl ester (), and isochlorogenic acid C-3'---glucopyranoside (), obtained along with thirteen known secondary metabolites belonging to distinct structural classes. The structures of the new metabolites were elucidated by modern spectroscopic techniues based on high-resolution mass spectrometry (HR-ESIMS) and 1D/2D nuclear magnetic resonance (NMR). All isolated compounds were tested for their potential antimicrobial activity against four different bacterial strains (, , , and ), in addition to a fungal strain (), The results were expressed as the diameter of the clear zone (in millimetres) around each well. Compounds and (isochlorogenic acid A-3'---glucopyranoside and isochlorogenic acid C-3'---glucopyranoside, respectively) displayed remarkable antifungal effect and potent antibacterial activities against and , respectively. 3,4-10-trihydroxy-8-acetyloxyguaian-12,6-olide () and angelicoidenol 2---d-glucopyranoside () emerged as interesting dual antibacterial (selective on )/antifungal agents.
对阿拉伯植物茎的植物化学研究提供了三种新的异绿原酸衍生物，即异绿原酸 A-3'-葡萄糖苷（）、异绿原酸 A-3'-葡萄糖苷甲酯（）和异绿原酸 C-3'-葡萄糖苷（），以及十三种属于不同结构类别的已知次生代谢物。新代谢物的结构通过基于高分辨率质谱（HR-ESIMS）和 1D/2D 核磁共振（NMR）的现代光谱技术阐明。所有分离出的化合物都测试了它们对四种不同细菌菌株（、、、和）以及一种真菌菌株（）的潜在抗菌活性，结果以每个孔周围的清晰区域直径（毫米）表示。化合物和（分别为异绿原酸 A-3'-葡萄糖苷和异绿原酸 C-3'-葡萄糖苷）表现出显著的抗真菌作用和对和的有效抗菌活性。3,4-10-三羟基-8-乙酰氧基-12,6-愈创木内酯（）和当归内酯 2---D-吡喃葡萄糖苷（）作为有趣的双重抗菌（选择性）/抗真菌剂出现。
