Chernigovskaia E V, Danilova O A, Belen'kiĭ M A
Probl Endokrinol (Mosk). 1988 Jan-Feb;34(1):60-4.
The reaction of neurosecretory cells of some hypothalamic centers of rats of different age to experimental change of the blood level of corticoids to elucidate their role in the regulation of function of the hypophyseoadrenocortical system was studied. Immunohistochemical methods revealed corticoliberin- and vasopressinergic cells in the hypothalamic paraventricular nucleus and vasopressinergic cells in the anterocommissural group of neurosecretory cells and in the supraoptic nucleus. The number of revealed corticoliberin-immunoreactive cells and the value of nucleoli of vasopressinergic cells served an indicator of the intensity of synthesis of neurohormones. In accordance with literature data there was an increase in the number of corticoliberin-immunoreactive cells after adrenalectomy. Vasopressinergic cells of the anterocommissural group were activated after true adrenalectomy. They responded by lowered activity to sham adrenalectomy. Small cell vasopressinergic elements of the paraventricular nucleus and, to a lesser degree, large cell elements responded by a rise of activity to true and sham adrenalectomy. It was assumed that vasopressinergic elements of the anterocommissural group were sensitive to the content of peripheral blood corticoids and were involved in the system of long negative feedback. Vasopressinergic elements, mostly small cells of the paraventricular nucleus, appeared to be responsible via the system of short negative feedback for maintaining the hypophyseal ACTH level.
研究了不同年龄大鼠下丘脑某些神经分泌细胞对血液中皮质激素水平实验性变化的反应，以阐明它们在垂体肾上腺皮质系统功能调节中的作用。免疫组织化学方法揭示了下丘脑室旁核中的促肾上腺皮质激素释放素能细胞和加压素能细胞，以及神经分泌细胞前连合组和视上核中的加压素能细胞。所揭示的促肾上腺皮质激素释放素免疫反应性细胞的数量和加压素能细胞的核仁值可作为神经激素合成强度的指标。根据文献数据，肾上腺切除术后促肾上腺皮质激素释放素免疫反应性细胞的数量增加。真正的肾上腺切除术后，前连合组的加压素能细胞被激活。它们对假肾上腺切除术的反应是活性降低。室旁核的小细胞加压素能成分以及程度较轻的大细胞成分对真正的和假的肾上腺切除术的反应是活性升高。据推测，前连合组的加压素能成分对外周血皮质激素的含量敏感，并参与长负反馈系统。加压素能成分，主要是室旁核的小细胞，似乎通过短负反馈系统负责维持垂体促肾上腺皮质激素水平。
