Department of Obstetrics and Gynecology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey,
Arch Gynecol Obstet. 2013 Dec;288(6):1279-83. doi: 10.1007/s00404-013-2869-x. Epub 2013 Jun 5.
To investigate the relationship between Helicobacter pylori (Hp) positivity and the severity of symptoms of nausea and vomiting in patients diagnosed with hyperemesis gravidarum (HG).
Prospective controlled.
Ninety patients with the diagnosis of HG below the 20th week gestation, who had no additional disease and 50 pregnant women with no complaints were enrolled in the study. According to the severity of symptoms, the patients were divided into three groups as group I, II and III (mild, moderate and severe, respectively). The Rhode's scoring system was used to determine the severity of HG symptoms. HpIgG and IgM levels were determined in the blood samples and Hp DNA positivity with PCR was investigated in the saliva.
In accordance with the Rhode's scoring system, 15.5 % of the pregnant women had mild, 58.9 % had moderate, and 25.6 % had severe symptoms (group I, II and III, respectively). HpIgG was determined as positive in 78.6, 84.9 and 82.6 % in groups I, II and III, respectively. HpIgM positivity was determined as 26.1 % only in group III (p = 0.847). HpDNA was determined as 7.2, 3.8, and 91.3 % in group I, II, and III, respectively (p<0.01). While HpIgG was positive in 60 %, HpDNA was found to be positive in 2 % and HpIgM was found to be negative in all the pregnant women in the control group.
A positive relationship between the symptoms of HG and Hp positivity was determined using PCR.
研究幽门螺杆菌（Hp）阳性与妊娠剧吐（HG）患者恶心和呕吐症状严重程度的关系。
前瞻性对照。
本研究纳入了 90 例孕 20 周以下诊断为 HG 的患者（无其他疾病）和 50 例无症状孕妇。根据症状严重程度，患者分为三组：I 组、II 组和 III 组（轻度、中度和重度）。采用 Rhode 评分系统确定 HG 症状严重程度。检测血 Hp IgG 和 IgM 水平，并通过 PCR 检测唾液 Hp DNA 阳性。
根据 Rhode 评分系统，15.5%的孕妇为轻度、58.9%为中度、25.6%为重度（I、II、III 组分别）。I、II、III 组 Hp IgG 阳性率分别为 78.6%、84.9%和 82.6%。仅在 III 组中 Hp IgM 阳性率为 26.1%（p=0.847）。I、II、III 组 Hp DNA 阳性率分别为 7.2%、3.8%和 91.3%（p<0.01）。在对照组中，60%的孕妇 Hp IgG 阳性，2%的孕妇 Hp DNA 阳性，且 Hp IgM 均为阴性。
PCR 显示 HG 症状与 Hp 阳性之间存在正相关关系。
