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聚乙二醇、迷迭香酸和氧化石墨烯改性聚乳酸电纺伤口敷料的制备与表征

Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide.

作者信息

Liu Chengyi, Du Guicai, Guo Qunqun, Li Ronggui, Li Changming, He Hongwei

机构信息

College of Life Sciences, Qingdao University, Qingdao 266071, China.

Schneider Institute of Industrial Technology, School of Automation, Qingdao University, Qingdao 266071, China.

出版信息

Nanomaterials (Basel). 2023 Jul 3;13(13):2000. doi: 10.3390/nano13132000.

DOI:10.3390/nano13132000
PMID:37446516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10343514/
Abstract

Polylactic acid (PLA) is a biodegradable polymer made from natural sources, and its electrospinning (e-spinning) nanofiber membrane doped with antibacterial ingredients is widely used in the field of medical dressings. In this research, 9 wt% of rosmarinic acid (RosA) and 0.04 wt% of graphite oxide (GO) with synergistic antibacterial activity were introduced into the e-spinning PLA precursor solution, and the obtained PLA nanofiber membrane showed good antibacterial properties and wound healing effects. At the same time, a nonionic amphiphilic polymer, polyethylene glycol (PEG), was also introduced into this system to improve the hydrophilicity of the e-spinning membrane for wound healing application. The morphological characterization showed the RosA/GO and PEG did not affect the e-spinning of PLA. The tests of mechanical performance and wettability demonstrated that PEG and RosA/GO incorporated in PLA have migrated easily to the surface of the fiber. The e-spun PLA/PEG/RosA/GO membrane showed good antibacterial activity and promoted initial wound healing quickly, which would be a promising application in wound dressing.

摘要

聚乳酸（PLA）是一种由天然来源制成的可生物降解聚合物，其掺杂有抗菌成分的静电纺丝（e纺丝）纳米纤维膜在医用敷料领域得到广泛应用。在本研究中，将具有协同抗菌活性的9 wt%迷迭香酸（RosA）和0.04 wt%氧化石墨烯（GO）引入到e纺丝PLA前驱体溶液中，所得PLA纳米纤维膜表现出良好的抗菌性能和伤口愈合效果。同时，还将一种非离子两亲聚合物聚乙二醇（PEG）引入该体系，以提高e纺丝膜的亲水性，用于伤口愈合应用。形态表征表明RosA/GO和PEG不影响PLA的e纺丝。力学性能和润湿性测试表明，掺入PLA中的PEG和RosA/GO很容易迁移到纤维表面。静电纺PLA/PEG/RosA/GO膜表现出良好的抗菌活性，并能快速促进伤口初期愈合，这在伤口敷料方面将具有广阔的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/e9e246e7b926/nanomaterials-13-02000-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/5e5a0af6db32/nanomaterials-13-02000-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/1de06d72adc8/nanomaterials-13-02000-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/45db18d43849/nanomaterials-13-02000-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/166e8435c6b0/nanomaterials-13-02000-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/d2ee3ed04e37/nanomaterials-13-02000-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/979593bdab84/nanomaterials-13-02000-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/d07d47057038/nanomaterials-13-02000-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/4334e41a6c62/nanomaterials-13-02000-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/915ef5e9961a/nanomaterials-13-02000-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/e9e246e7b926/nanomaterials-13-02000-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/5e5a0af6db32/nanomaterials-13-02000-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/1de06d72adc8/nanomaterials-13-02000-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/45db18d43849/nanomaterials-13-02000-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/166e8435c6b0/nanomaterials-13-02000-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/d2ee3ed04e37/nanomaterials-13-02000-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/979593bdab84/nanomaterials-13-02000-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/d07d47057038/nanomaterials-13-02000-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/4334e41a6c62/nanomaterials-13-02000-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/915ef5e9961a/nanomaterials-13-02000-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7570/10343514/e9e246e7b926/nanomaterials-13-02000-g010.jpg

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本文引用的文献

[1]
Electrospun Nanofibers for Dura Mater Regeneration: A Mini Review on Current Progress.

Pharmaceutics. 2023-4-27

[2]
Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing.

Int J Biol Macromol. 2023-4-15

[3]
Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing.

ACS Appl Bio Mater. 2022-8-18

[4]
Single-Side Superhydrophobicity in SiN-Doped and SiO-Treated Polypropylene Nonwoven Webs with Antibacterial Activity.

Polymers (Basel). 2022-7-21

[5]
A Multifunctional Janus Electrospun Nanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial Properties for Wound Healing.

ACS Appl Mater Interfaces. 2022-3-23

[6]
Tailoring moisture electroactive Ag/Zn@cotton coupled with electrospun PVDF/PS nanofibers for antimicrobial face masks.

J Hazard Mater. 2022-4-15

[7]
Latest Progress in Electrospun Nanofibers for Wound Healing Applications.

ACS Appl Bio Mater. 2019-3-18

[8]
Recent Progress in Protective Membranes Fabricated via Electrospinning: Advanced Materials, Biomimetic Structures, and Functional Applications.

Adv Mater. 2022-4

[9]
Novel PLA/ZnO Nanofibrous Nanocomposite Loaded with Tranexamic Acid as an Effective Wound Dressing: and Assessment.

Iran J Biotechnol. 2021-7-1

[10]
Electrospun Medicated Nanofibers for Wound Healing: Review.

Membranes (Basel). 2021-10-9

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