Paris-Saclay Institute of Neurosciences (Neuro-PSI),University Paris-Sud,CNRS, andParis-Saclay University,91405 Orsay Cedex,
Behav Brain Sci. 2016 Jan;39:e208. doi: 10.1017/S0140525X1500179X.
Mather and colleagues' arguments require rethinking at the mechanistic level. The arguments on the physiological effects of norepinephrine at the cortical level are inconsistent with large parts of the literature. There is no evidence that norepinephrine induces local "hotspots": Norepinephrine mainly decreases evoked responses; facilitating effects are rare and not localized. More generally, the idea that perception benefits from "local hotspots" is hardly compatible with the fact that neural representations involve largely distributed activation of cortical and subcortical networks.
马瑟和同事们的观点需要在机制层面上重新思考。他们关于去甲肾上腺素在皮质水平上对生理效应的观点与大部分文献不一致。没有证据表明去甲肾上腺素会诱导局部“热点”：去甲肾上腺素主要会降低诱发反应；促进作用很少见，也不具有局部性。更一般地说，认为感知受益于“局部热点”的观点与这样一个事实是相悖的，即神经表示涉及皮质和皮质下网络的广泛分布激活。
