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The impact of environment on abnormal behavior and mental disease: To alleviate the prevalence of mental disorders, we need to phenotype the environment for risk factors.环境对异常行为和精神疾病的影响：为了减轻精神障碍的流行，我们需要对环境中的风险因素进行表型分析。
EMBO Rep. 2017 May;18(5):661-665. doi: 10.15252/embr.201744197. Epub 2017 Mar 27.
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OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.OTTO：一种从个体中提取与精神疾病相关的 GWAS 命中组合的新策略。
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Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect.《失落的天堂：儿童虐待和忽视的神经生物学及临床后果》
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Accumulated environmental risk determining age at schizophrenia onset: a deep phenotyping-based study.累积环境风险决定精神分裂症发病年龄：一项基于深度表型分析的研究。
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Myelination and oligodendrocyte functions in psychiatric diseases.精神疾病中的髓鞘形成与少突胶质细胞功能
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Head injury as risk factor for psychiatric disorders: a nationwide register-based follow-up study of 113,906 persons with head injury.颅脑损伤作为精神障碍的危险因素：一项针对 113906 例颅脑损伤患者的全国范围内基于登记的随访研究。
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City living and urban upbringing affect neural social stress processing in humans.城市生活和城市教养影响人类神经社会压力处理。
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Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics.精神分裂症的双胞胎研究：从弓箭一致性到《星球大战》中的Mx和功能基因组学
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Multiple risk factors in the development of externalizing behavior problems: group and individual differences.外化行为问题发展中的多种风险因素：群体和个体差异。
Dev Psychopathol. 1998 Summer;10(3):469-93. doi: 10.1017/s0954579498001709.

环境对异常行为和精神疾病的影响：为了减轻精神障碍的流行，我们需要对环境中的风险因素进行表型分析。

The impact of environment on abnormal behavior and mental disease: To alleviate the prevalence of mental disorders, we need to phenotype the environment for risk factors.

机构信息

Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

出版信息

EMBO Rep. 2017 May;18(5):661-665. doi: 10.15252/embr.201744197. Epub 2017 Mar 27.

DOI:10.15252/embr.201744197
PMID:28348000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5412816/
Abstract

The risk of mental diseases is determined by both genetic and environmental factors, the latter of which may have an even greater impact. To assess individual risk and design efficient preventive measures will require phenotyping environmental risk factors. [Image: see text]

摘要

精神疾病的风险由遗传和环境因素共同决定，后者的影响可能更大。评估个体风险并设计有效的预防措施需要表型分析环境风险因素。[图片：见正文]