Misra M, Audoly B, Shvartsman S Y
Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Philos Trans R Soc Lond B Biol Sci. 2017 May 19;372(1720). doi: 10.1098/rstb.2015.0515.
The formation of three-dimensional structures from patterned epithelial sheets plays a key role in tissue morphogenesis. An important class of morphogenetic mechanisms relies on the spatio-temporal control of apical cell contractility, which can result in the localized bending of cell sheets and in-plane cell rearrangements. We have recently proposed a modified vertex model that can be used to systematically explore the connection between the two-dimensional patterns of cell properties and the emerging three-dimensional structures. Here we review the proposed modelling framework and illustrate it through the computational analysis of the vertex model that captures the salient features of the formation of the dorsal appendages during oogenesis.This article is part of the themed issue 'Systems morphodynamics: understanding the development of tissue hardware'.
由图案化上皮细胞层形成三维结构在组织形态发生中起关键作用。一类重要的形态发生机制依赖于顶端细胞收缩性的时空控制，这可导致细胞层的局部弯曲和平面内细胞重排。我们最近提出了一种改进的顶点模型，可用于系统地探索细胞特性的二维模式与新兴三维结构之间的联系。在此，我们回顾所提出的建模框架，并通过对顶点模型的计算分析来说明它，该顶点模型捕捉了卵子发生过程中背侧附属物形成的显著特征。本文是主题为“系统形态动力学：理解组织硬件的发育”的特刊的一部分。
