鉴别Leber遗传性视神经病变与正常眼压性青光眼。
Differentiating Leber Hereditary Optic Neuropathy from Normal-Tension Glaucoma.
作者信息
Souto Fernanda Maria Silveira, de Vasconcellos José Paulo Cabral, de Melo Mônica Barbosa, Sartorato Edi Lúcia, Moura Frederico Castelo
机构信息
Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas , Campinas, São Paulo, Brazil.
Center for Molecular Biology and Genetic Engineering, University of Campinas , Campinas, São Paulo, Brazil.
出版信息
Neuroophthalmology. 2017 Feb 17;41(2):99-102. doi: 10.1080/01658107.2017.1279185. eCollection 2017 Apr.
Glaucoma is a neurodegenerative disorder characterized by thinning of neuroretinal rim, enlarged cup-to-disc ratio (CDR) and visual field damage. Although raised intraocular pressure is main risk factor for development of glaucoma, it can occur with consistently normal measurements in the intraocular pressure as normal tension glaucoma (NTG). Enlargement of CDR is a classical sign of glaucoma, but it can also result from non-glaucomatous optic neuropathies such as Leber hereditary optic neuropathy (LHON). We describe a case of LHON with increased CDR, discuss its differential diagnosis with NTG and highlight the reasons for misdiagnoses between these two entities.
青光眼是一种神经退行性疾病，其特征为神经视网膜边缘变薄、杯盘比（CDR）增大和视野损害。虽然眼压升高是青光眼发病的主要危险因素，但在眼压测量始终正常的情况下也可能发生，即正常眼压性青光眼（NTG）。CDR增大是青光眼的典型体征，但也可能由非青光眼性视神经病变引起，如Leber遗传性视神经病变（LHON）。我们描述了一例CDR增加的LHON病例，讨论了其与NTG的鉴别诊断，并强调了这两种疾病之间误诊的原因。
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