利福平与苄青霉素联合瓣膜置换术成功治疗人工瓣膜心内膜炎
Successful treatment of prosthetic valve endocarditis using rifampicin and benzylpenicillin in combination with valve replacement.
作者信息
Hasan Tasnim, Chik William, Chen Sharon, Kok Jen
机构信息
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital , Westmead, New South Wales , Australia.
Department of Cardiology, Westmead Hospital , Westmead, New South Wales , Australia.
出版信息
JMM Case Rep. 2017 Feb 28;4(2):e005085. doi: 10.1099/jmmcr.0.005085. eCollection 2017 Feb.
is an uncommon cause of prosthetic valve endocarditis (PVE). Recommended antimicrobial therapy typically includes intravenous β-lactams with or without synergistic aminoglycosides. studies have previously identified antagonism when rifampicin has been used in combination with β-lactams. However, data of rifampicin use are limited despite its enhanced anti-biofilm activity. A 63-year-old male presented with fever and back pain. bacteraemia and bioprosthetic aortic valve endocarditis was confirmed, along with spinal discitis and osteomyelitis. He was successfully treated with benzylpenicillin and rifampicin, in conjunction with valve replacement. Rifampicin remains an alternate agent to use, when there are contraindications to traditional aminoglycoside therapy. Further data on rifampicin use in PVE are awaited.
是人工瓣膜心内膜炎（PVE）的一种罕见病因。推荐的抗菌治疗通常包括静脉注射β-内酰胺类药物，可联合或不联合具有协同作用的氨基糖苷类药物。此前的研究已发现利福平与β-内酰胺类药物联合使用时存在拮抗作用。然而，尽管利福平具有增强的抗生物膜活性，但其使用数据有限。一名63岁男性出现发热和背痛。确诊为菌血症和生物人工主动脉瓣心内膜炎，同时伴有椎间盘炎和骨髓炎。他接受苄星青霉素和利福平治疗，并进行了瓣膜置换，治疗成功。当传统氨基糖苷类治疗存在禁忌证时，利福平仍是一种可供选择的药物。期待关于利福平在PVE中使用的更多数据。
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