Department of Medicine, McMaster University, Hamilton, ON, Canada.
Joseph Brant Hospital, Burlington, ON, Canada.
BMC Infect Dis. 2020 Jul 31;20(1):559. doi: 10.1186/s12879-020-05286-y.
Listeriosis is a severe food-borne infection caused by the Gram-positive rod, Listeria monocytogenes. Despite the low incidence (3-8 cases per million), Listeriosis has a case fatality rate of 20-30% as it occurs predominantly in immunocompromised individuals at extremes of age, diabetics and pregnant women. Listeriosis classically presents as a febrile gastroenteritis, isolated bacteremia, meningitis, or maternal-fetal infections. Focal bone and joint infection are rare and primarily involve orthopedic implant devices. Here, we present the first case of Listeria-associated spondylodiscitis.
A 79-year-old male presents with acute-on-chronic back pain in the absence of risk factors or exposures, aside from age. On radiological imaging, spondylodiscitis of L3-L4 was diagnosed. Subsequently, a CT-guided biopsy was performed to aid in confirming microbiological aetiology. Listeria monocytogenes was grown in culture and patient received appropriate antibacterial therapy.
The case highlights the utility of image-guided tissue sampling in aiding diagnosis and management in patients with vertebral osteomyelitis. It also encourages consideration of uncommon organisms such as Listeria as an etiology of vertebral osteomyelitis, even in the absence of prosthetic implants.
李斯特菌病是一种由革兰阳性杆菌李斯特菌引起的严重食源性感染。尽管发病率较低(每百万人中有 3-8 例),但李斯特菌病的病死率仍为 20-30%,因为它主要发生在免疫功能低下的人群(如老年人、糖尿病患者和孕妇)中。李斯特菌病典型表现为发热性肠胃炎、孤立性菌血症、脑膜炎或母婴感染。局限性骨和关节感染较为罕见,主要涉及骨科植入物。在此,我们报告首例李斯特菌相关性椎间盘炎。
一名 79 岁男性因无明确诱因(除年龄外)出现慢性腰痛急性发作就诊。影像学检查诊断为 L3-L4 椎间盘炎。随后进行 CT 引导下活检以协助确定微生物病因。培养出李斯特菌,患者接受了适当的抗菌治疗。
该病例强调了影像学引导下组织采样在协助诊断和管理椎体骨髓炎患者中的作用。它还鼓励考虑李斯特菌等罕见病原体作为椎体骨髓炎的病因,即使没有假体植入物。