菲律宾恶性疟原虫的体外药物反应：对氨酚喹的耐药性增加。
In vitro drug response of Plasmodium falciparum in the Philippines: increased resistance to amodiaquine.
作者信息
Long G W, Watt G, Sy N, Buck R L, Sangalang R P, Ranoa C P
机构信息
U.S. Naval Medical Research Unit No. 2, Manila, Philippines.
出版信息
Southeast Asian J Trop Med Public Health. 1987 Jun;18(2):202-6.
A long term study was carried out at San Lazaro Hospital, Manila, Philippines, monitoring the in vitro response of Plasmodium falciparum to chloroquine, amodiaquine, mefloquine, and quinine. The in vitro effective dose giving 50% inhibition of schizogony was: 0.68 X 10(-6) M/liter blood for chloroquine; 0.18 X 10(-6) for amodiaquine; 0.2 X 10(-6) for mefloquine; and 1.12 X 10(-6) for quinine. The percent of isolates determined to be resistant in vitro was 85.2% for chloroquine, and 1.2% for both mefloquine and quinine. These figures were relatively unchanged over the course of 3 years studied. The in vitro resistance rate to amodiaquine increased from 5.1% in 1982 to 22.2% in 1984.
在菲律宾马尼拉的圣拉萨罗医院开展了一项长期研究，监测恶性疟原虫对氯喹、氨酚喹、甲氟喹和奎宁的体外反应。产生50%裂殖体发育抑制的体外有效剂量为：氯喹，每升血液0.68×10⁻⁶摩尔；氨酚喹，0.18×10⁻⁶；甲氟喹，0.2×10⁻⁶；奎宁，1.12×10⁻⁶。体外测定为耐药的分离株百分比，氯喹为85.2%，甲氟喹和奎宁均为1.2%。在研究的3年期间，这些数字相对没有变化。对氨酚喹的体外耐药率从1982年的5.1%升至1984年的22.2%。
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