Zeng Jinrong, Luo Shuaihantian, Huang Yumeng, Lu Qianjin
Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital of Central South University, Changsha, China.
J Dermatol. 2017 Aug;44(8):863-872. doi: 10.1111/1346-8138.13806. Epub 2017 Mar 27.
Psoriasis is a common cutaneous disease with multifactorial etiology including genetic and non-genetic factors, such as drugs, smoking, drinking, diet, infection and mental stress. Now, the role of the interaction between environmental factors and genetics are considered to be a main factor in the pathogenesis of psoriasis. However, it is a challenge to explore the mechanisms how the environmental factors break the body balance to affect the onset and development of psoriasis. In this article, we review the pathogenesis of psoriasis and summarize numerous clinical data to reveal the association between environmental factors and psoriasis. In addition, we focus on the mechanisms of environmental risk factors impact on psoriasis and provide a series of potential treatments against environmental risk factors.
银屑病是一种常见的皮肤病，其病因是多因素的，包括遗传和非遗传因素，如药物、吸烟、饮酒、饮食、感染和精神压力。目前，环境因素与遗传之间的相互作用被认为是银屑病发病机制中的一个主要因素。然而，探索环境因素如何打破身体平衡以影响银屑病的发生和发展的机制是一项挑战。在本文中，我们综述了银屑病的发病机制，并总结了大量临床数据以揭示环境因素与银屑病之间的关联。此外，我们重点关注环境危险因素对银屑病的影响机制，并提供一系列针对环境危险因素的潜在治疗方法。
