Shao Xinyi, Ou Yi, Liu Qian, Fu Yidian, Pan Yan, Chen Aijun, Bai Genlong, Zhang Jingbo
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Graduate School of Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Eur J Med Res. 2025 Aug 12;30(1):739. doi: 10.1186/s40001-025-03002-7.
Psoriasis is a persistent inflammatory skin condition. Several studies have revealed that obesity significantly contributes to both the initiation and advancement of psoriasis. The metabolic score for visceral fat (METS-VF) represents an innovative measure designed to forecast visceral obesity, integrating factors such as insulin resistance metabolic score, waist-to-hip ratio (WHR), age, and gender. The present study aimed to investigate the association between METS-VF and psoriasis prevalence, using information gathered from the National Health and Nutrition Examination Survey (NHANES).
This study utilized the data from a nationally representative cohort of 8023 adults from NHANES from 2003-2006 to 2009-2014, of which 234 declared a psoriasis history. Multivariate logistic regression analysis and restricted cubic spline (RCS) analyses were used to investigate the association between METS-VF and psoriasis, followed by subgroup analysis to identify populations that may exhibit higher sensitivity.
After adjusting for confounding variables, the results of the multivariate logistic regression analysis showed a significant positive association between METS-VF and the risk of psoriasis. One-unit increasement in METS-VF corresponded to a 47% rise in psoriasis risk (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.96). Finally, the results were uniform across all subgroups (P > 0.05). The results from the RCS analysis indicated a notable linear association.
This research indicated that elevated levels of METS-VF are linked to a higher occurrence of psoriasis, suggesting the potential of METS-VF as a predictive anthropometric index for assessing the risk of developing psoriasis.
银屑病是一种持续性炎症性皮肤病。多项研究表明，肥胖显著促进银屑病的发生和发展。内脏脂肪代谢评分（METS-VF）是一种旨在预测内脏肥胖的创新指标，综合了胰岛素抵抗代谢评分、腰臀比（WHR）、年龄和性别等因素。本研究旨在利用从国家健康与营养检查调查（NHANES）收集的信息，调查METS-VF与银屑病患病率之间的关联。
本研究利用了2003年至2006年至2009年至2014年NHANES中具有全国代表性的8023名成年人队列的数据，其中234人宣称有银屑病病史。采用多因素logistic回归分析和受限立方样条（RCS）分析来研究METS-VF与银屑病之间的关联，随后进行亚组分析以确定可能表现出更高敏感性的人群。
在调整混杂变量后，多因素logistic回归分析结果显示METS-VF与银屑病风险之间存在显著正相关。METS-VF每增加一个单位，银屑病风险相应增加47%（比值比[OR]=1.47，95%置信区间[CI]=1.10-1.96）。最后，所有亚组的结果均一致（P>0.05）。RCS分析结果表明存在显著的线性关联。
本研究表明，METS-VF水平升高与银屑病的较高发生率相关，提示METS-VF作为评估银屑病发病风险的预测性人体测量指标的潜力。
