T细胞对爱泼斯坦-巴尔病毒感染的B细胞的细胞毒性：类风湿性关节炎患者与其HLA相同的同胞的比较。
T cell cytotoxicity to Epstein-Barr virus infected B cells: comparison of patients with rheumatoid arthritis and their HLA identical siblings.
作者信息
Winrow V R, Norton J, Holborow E J, Stierle H E, Young A, Sachs J A
机构信息
ARC Bone and Joint Research Unit, London Hospital Medical College, England.
出版信息
Ann Rheum Dis. 1988 Apr;47(4):280-5. doi: 10.1136/ard.47.4.280.
Abstract
Specific T cell cytotoxicity to Epstein-Barr virus (EBV) infected B cells is reported to be abnormal in rheumatoid arthritis (RA). The regression phenomenon was used to determine whether the immunoregulatory defect in RA is restricted to T cells, B cells, or HLA type. Peripheral blood T and B cells from patients with RA and their HLA identical healthy siblings were mixed in varying ratios with and without EBV, and thymidine incorporation was measured on days 7, 14, and 21. The results suggest that the T cell abnormality is related to disease activity and that an inherent defect exists in the rheumatoid B cell which is independent of disease activity.
摘要
据报道，类风湿性关节炎（RA）患者针对爱泼斯坦-巴尔病毒（EBV）感染的B细胞的特异性T细胞细胞毒性异常。采用回归现象来确定RA中的免疫调节缺陷是否仅限于T细胞、B细胞或HLA类型。将RA患者及其HLA相同的健康同胞的外周血T细胞和B细胞以不同比例混合，分别加入或不加入EBV，并在第7天、14天和21天测量胸腺嘧啶核苷掺入量。结果表明，T细胞异常与疾病活动相关，类风湿性B细胞存在固有缺陷，且该缺陷与疾病活动无关。
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本文引用的文献
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Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation.类风湿关节炎淋巴细胞导致爱泼斯坦-巴尔病毒诱导的B细胞增殖调节受损的缺陷分析。I. 自体刺激后γ干扰素产生减少。
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