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与未富集的基质血管成分相比,纯化的脂肪来源基质细胞具有更好的脂肪移植保留率。

Purified Adipose-Derived Stromal Cells Provide Superior Fat Graft Retention Compared with Unenriched Stromal Vascular Fraction.

作者信息

Zielins Elizabeth R, Brett Elizabeth A, Blackshear Charles P, Flacco John, Ransom Ryan C, Longaker Michael T, Wan Derrick C

机构信息

Stanford, Calif.

From the Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, and the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University.

出版信息

Plast Reconstr Surg. 2017 Apr;139(4):911-914. doi: 10.1097/PRS.0000000000003165.


DOI:10.1097/PRS.0000000000003165
PMID:28350672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5398091/
Abstract

Cell-assisted lipotransfer has shown much promise as a technique to improve fat graft retention in both mouse and human studies. However, the literature varies as to whether fresh stromal vascular fraction or culture-expanded adipose-derived stromal cells are used to augment volume retention. The authors' study sought to determine whether there was a significant advantage to using adipose-derived stromal cells over unpurified stromal vascular fraction cells in a mouse model of cell-assisted lipotransfer.

摘要

在小鼠和人体研究中,细胞辅助脂肪移植作为一种提高脂肪移植保留率的技术已显示出很大的前景。然而,关于使用新鲜的基质血管成分还是培养扩增的脂肪来源基质细胞来增加体积保留率,文献说法不一。作者的研究旨在确定在细胞辅助脂肪移植的小鼠模型中,使用脂肪来源基质细胞相对于未纯化的基质血管成分细胞是否具有显著优势。

相似文献

[1]
Purified Adipose-Derived Stromal Cells Provide Superior Fat Graft Retention Compared with Unenriched Stromal Vascular Fraction.

Plast Reconstr Surg. 2017-4

[2]
The Fate of the Adipose-Derived Stromal Cells during Angiogenesis and Adipogenesis after Cell-Assisted Lipotransfer.

Plast Reconstr Surg. 2018-2

[3]
Studies in fat grafting: Part IV. Adipose-derived stromal cell gene expression in cell-assisted lipotransfer.

Plast Reconstr Surg. 2015-4

[4]
Systemic Administration of Adipose-Derived Stromal Cells Concurrent with Fat Grafting.

Plast Reconstr Surg. 2019-5

[5]
Cell-Enriched Fat Grafting Improves Graft Retention in a Porcine Model: A Dose-Response Study of Adipose-Derived Stem Cells versus Stromal Vascular Fraction.

Plast Reconstr Surg. 2019-9

[6]
Improved Long-Term Volume Retention of Stromal Vascular Fraction Gel Grafting with Enhanced Angiogenesis and Adipogenesis.

Plast Reconstr Surg. 2018-5

[7]
Mechanical Supplementation With the Stromal Vascular Fraction Yields Improved Volume Retention in Facial Lipotransfer: A 1-Year Comparative Study.

Aesthet Surg J. 2017-10-1

[8]
Effect of Cryopreservation on Human Adipose Tissue and Isolated Stromal Vascular Fraction Cells: In Vitro and In Vivo Analyses.

Plast Reconstr Surg. 2018-2

[9]
Fat Grafting for Facial Contouring Using Mechanically Stromal Vascular Fraction-Enriched Lipotransfer.

Clin Plast Surg. 2019-10-25

[10]
Enhanced Effect of Secondary Administration of Adipose-Derived Stromal Cells Concurrent with Fat Grafting.

Plast Reconstr Surg. 2024-2-1

引用本文的文献

[1]
Adipose derived stromal vascular fraction and fat graft for treating the hands of patients with systemic sclerosis. A randomized clinical trial.

PLoS One. 2023

[2]
Adipose-derived stem cells regulate CD4+ T-cell-mediated macrophage polarization and fibrosis in fat grafting in a mouse model.

Heliyon. 2022-11-9

[3]
Strategies to Improve AFT Volume Retention After Fat Grafting.

Aesthetic Plast Surg. 2023-4

[4]
Breast Reconstruction- Developing a Volumetric Outcome Algorithm.

Aesthetic Plast Surg. 2022-8

[5]
Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model.

Stem Cell Res Ther. 2020-11-19

[6]
Fat grafts enriched with adipose-derived stem cells.

Arch Craniofac Surg. 2020-8

[7]
How Fat Grafting Works.

Plast Reconstr Surg Glob Open. 2020-7-14

[8]
Ex vivo-expanded autologous adipose tissue-derived stromal cells ensure enhanced fat graft retention in breast augmentation: A randomized controlled clinical trial.

Stem Cells Transl Med. 2020-11

本文引用的文献

[1]
Cell-Assisted Lipotransfer: A Systematic Review of Its Efficacy.

Aesthetic Plast Surg. 2016-4

[2]
Efficacy and Safety of Cell-Assisted Lipotransfer: A Systematic Review and Meta-Analysis.

Plast Reconstr Surg. 2016-1

[3]
Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports (Review).

Mol Med Rep. 2016-2

[4]
Cell-Assisted Lipotransfer Improves Volume Retention in Irradiated Recipient Sites and Rescues Radiation-Induced Skin Changes.

Stem Cells. 2016-3

[5]
Studies in Fat Grafting: Part V. Cell-Assisted Lipotransfer to Enhance Fat Graft Retention Is Dose Dependent.

Plast Reconstr Surg. 2015-7

[6]
Isolation and enrichment of human adipose-derived stromal cells for enhanced osteogenesis.

J Vis Exp. 2015-1-12

[7]
Assessment of viability of human fat injection into nude mice with micro-computed tomography.

J Vis Exp. 2015-1-7

[8]
Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells.

PLoS One. 2014-12-26

[9]
Prevalence of endogenous CD34+ adipose stem cells predicts human fat graft retention in a xenograft model.

Plast Reconstr Surg. 2013-10

[10]
Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).

Cytotherapy. 2013-4-6

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