[乳腺癌中胎儿胸苷激酶与胸苷酸激酶活性之间的密切关系]
[Close relation between fetal thymidine kinase and thymidylate kinase activities in breast cancer].
作者信息
Madec A, Maquaire E, Javre J L, Amoros M, Samperez S, Jouan P
机构信息
Centre régional de Recherche en Endocrinologie, Faculté de Médecine-Pharmacie, Rennes.
出版信息
C R Seances Soc Biol Fil. 1987;181(5):495-501.
PMID:2835129
Abstract
In human breast cancers, assays on thymidine kinase activity revealed the synthesis of large amounts of d-TTP. This fact suggested the presence of thymidylate kinase closely associated with thymidine kinase. Results obtained with experimental tumors were quite different. These tumors appeared inadequate for the study on thymidine metabolism in mammary cancers.
摘要
在人类乳腺癌中，对胸苷激酶活性的检测显示合成了大量的脱氧胸苷三磷酸（d-TTP）。这一事实表明存在与胸苷激酶紧密相关的胸苷酸激酶。实验性肿瘤的检测结果则大不相同。这些肿瘤似乎不适用于乳腺肿瘤中胸苷代谢的研究。
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