Javre J L, Hannouche N, Samperez S, Jouan P
Bull Cancer. 1986;73(1):8-16.
Seventy five human breast cancers were examined in order to search for the presence of thymidine kinase of the fetal-type (TK-F). The presence of TK-F was evidenced in all tumors. Its activity varied from one to another tumor, but it was evident that the increased TK activity observed in mammary cancers could exclusively be related to high TK-F activity. Some relations between TK-F activity and the presence of estradiol and progesterone receptors (ER, PR) were obvious. The highest activities were observed in cancers with high level of ER and PR. Thymidylate kinase activity (d-TTP synthesis) varied in parallel with TK-F activity. In a general way, it was higher in ER+ PR+ than in ER+ PR- cancers.
为了寻找胎儿型胸苷激酶（TK-F）的存在，对75例人类乳腺癌进行了检查。在所有肿瘤中均证实存在TK-F。其活性在不同肿瘤之间有所差异，但很明显，在乳腺癌中观察到的胸苷激酶活性增加完全与高TK-F活性有关。TK-F活性与雌二醇和孕酮受体（ER、PR）的存在之间存在一些明显的关系。在ER和PR水平高的癌症中观察到最高活性。胸苷酸激酶活性（d-TTP合成）与TK-F活性平行变化。一般来说，ER+PR+癌症中的活性高于ER+PR-癌症。
