Madec-Baron A, Baron G, Sampérez S, Jouan P
Centre régional de Recherche en Endocrinologie, Faculté de Médecine-Pharmacie, Rennes.
C R Acad Sci III. 1989;309(17):669-73.
An unusual form of thymidine kinase has been found in cytosols from breast cancers. It differs from the adult and fetal isoenzymes of thymidine kinase in so far as its activity could not be isolated from that of thymidylate kinase. Following sucrose density gradients, electrofocusing, ion exchange chromatography or molecular sieving, both activities appeared as a single peak. These facts suggest that they could be attributed to a single multifunctional protein.
在乳腺癌细胞溶质中发现了一种不寻常形式的胸苷激酶。它与胸苷激酶的成人及胎儿同工酶不同，因为其活性无法与胸苷酸激酶的活性分离。经过蔗糖密度梯度离心、等电聚焦、离子交换色谱或分子筛分离后，两种活性均呈现为单一峰。这些事实表明它们可能归因于一种单一的多功能蛋白。
