药物治疗：利用合成致死性改善癌症治疗。 - Suppr

Drug therapy: Exploiting synthetic lethality to improve cancer therapy.

作者信息

Brunen Diede, Bernards René

机构信息

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

出版信息

Nat Rev Clin Oncol. 2017 Jun;14(6):331-332. doi: 10.1038/nrclinonc.2017.46. Epub 2017 Mar 29.

DOI:10.1038/nrclinonc.2017.46

PMID:28352131

Abstract

摘要

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Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.伊马替尼治疗慢性髓性白血病的长期疗效

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Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.染色质重塑因子CHD1在PTEN缺陷型癌症中的合成必需性

Nature. 2017 Feb 23;542(7642):484-488. doi: 10.1038/nature21357. Epub 2017 Feb 6.

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.基因必需性分析揭示基因网络以及与致癌性Ras的合成致死相互作用。

Cell. 2017 Feb 23;168(5):890-903.e15. doi: 10.1016/j.cell.2017.01.013. Epub 2017 Feb 2.

Opportunities and challenges provided by crosstalk between signalling pathways in cancer.癌症中信号通路间相互作用所带来的机遇与挑战

Oncogene. 2016 Mar 3;35(9):1073-9. doi: 10.1038/onc.2015.151. Epub 2015 May 18.

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.结直肠癌对 BRAF(V600E)抑制的无应答性通过 EGFR 的反馈激活。

Nature. 2012 Jan 26;483(7387):100-3. doi: 10.1038/nature10868.

Non-oncogene addiction and the stress phenotype of cancer cells.非癌基因成瘾与癌细胞的应激表型

Cell. 2007 Sep 21;130(6):986-8. doi: 10.1016/j.cell.2007.09.007.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.将BRCA突变细胞中的DNA修复缺陷作为一种治疗策略。

Nature. 2005 Apr 14;434(7035):917-21. doi: 10.1038/nature03445.

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.用聚（ADP - 核糖）聚合酶抑制剂特异性杀伤BRCA2缺陷型肿瘤

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Cancer. Addiction to oncogenes--the Achilles heal of cancer.癌症。对癌基因的依赖——癌症的阿喀琉斯之踵。

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Drug therapy: Exploiting synthetic lethality to improve cancer therapy.

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