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Drug therapy: Exploiting synthetic lethality to improve cancer therapy.

作者信息

Brunen Diede, Bernards René

机构信息

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

出版信息

Nat Rev Clin Oncol. 2017 Jun;14(6):331-332. doi: 10.1038/nrclinonc.2017.46. Epub 2017 Mar 29.

DOI:10.1038/nrclinonc.2017.46
PMID:28352131
Abstract
摘要

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Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.染色质重塑因子CHD1在PTEN缺陷型癌症中的合成必需性
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A Novel Platform to Test In Vivo Single Gene Dependencies in t(8,21) and t(15,17) AML Confirms Zeb2 as Leukemia Target.一种用于检测t(8,21)和t(15,17)急性髓系白血病体内单基因依赖性的新型平台证实Zeb2为白血病靶点。
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