Schille Carolin, Schambony Alexandra
Biology Department, Developmental Biology, Friedrich-Alexander University Erlangen-Nuremberg , Erlangen, Germany.
Neurogenesis (Austin). 2017 Feb 23;4(1):e1292783. doi: 10.1080/23262133.2017.1292783. eCollection 2017.
The neural crest is a transient cell population that gives rise to various cell types of multiple tissues and organs in the vertebrate embryo. Neural crest cells arise from the neural plate border, a region localized at the lateral borders of the prospective neural plate. Temporally and spatially coordinated interaction with the adjacent tissues, the non-neural ectoderm, the neural plate and the prospective dorsolateral mesoderm, is required for neural plate border specification. Signaling molecules, namely BMP, Wnt and FGF ligands and corresponding antagonists are derived from these tissues and interact to induce the expression of neural plate border specific genes. The present mini-review focuses on the current understanding of how the NPB territory is formed and accentuates the need for coordinated interaction of BMP and Wnt signaling pathways and precise tissue communication that are required for the definition of the prospective NC in the competent ectoderm.
神经嵴是一种短暂存在的细胞群体，在脊椎动物胚胎中产生多种组织和器官的各种细胞类型。神经嵴细胞起源于神经板边界，即位于预期神经板外侧边缘的一个区域。神经板边界的特化需要与相邻组织，即非神经外胚层、神经板和预期的背外侧中胚层进行时间和空间上协调的相互作用。信号分子，即骨形态发生蛋白（BMP）、Wnt和FGF配体以及相应的拮抗剂，源自这些组织并相互作用以诱导神经板边界特异性基因的表达。本综述聚焦于目前对神经板边界区域如何形成的理解，并强调了BMP和Wnt信号通路协调相互作用以及精确的组织通讯对于在外胚层中确定预期神经嵴的必要性。
