Department of Developmental Biology, Stanford University, Stanford, California 94305, USA.
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10):a007914. doi: 10.1101/cshperspect.a007914.
In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a variety of other responses. These are often lumped together under the denominator "alternative" or "non-canonical" Wnt signaling, but they likely comprise distinct signaling events. In this article, I discuss how the use of different ligand and receptor combinations is thought to give rise to these alternative Wnt-signaling responses. Although many of the biochemical details remain to be resolved, it is evident that alternative Wnt signaling plays important roles in regulating tissue morphogenesis during embryonic development.
除了激活β-连环蛋白/TCF 转录复合物外，Wnt 蛋白还可以引发多种其他反应。这些反应通常被归为“非经典”或“替代”Wnt 信号，但它们可能包含不同的信号事件。在本文中，我将讨论不同配体和受体组合的使用如何导致这些替代 Wnt 信号反应。尽管许多生化细节仍有待解决，但很明显，替代 Wnt 信号在调节胚胎发育过程中的组织形态发生中发挥着重要作用。
