代谢综合征男性餐后低密度脂蛋白胆固醇的降低

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome.

作者信息

Skoczyńska Anna, Turczyn Barbara, Wojakowska Anna, Kreczyńska Bogusława, Skoczyńska Marta, Wojtas Kamila

机构信息

Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wrocław, Poland, tel.: 71-7364005, fax: 71-7364009.

Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.

出版信息

Open Med (Wars). 2015 Feb 3;10(1):138-151. doi: 10.1515/med-2015-0025. eCollection 2015.

BACKGROUND

In some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy).

METHODS

36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apolipoproteins A-I, B, and hsCRP immunoturbidimetrically.

RESULTS

The postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-cholesterol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy.

CONCLUSION

In men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.

背景

在一些流行病学研究中，血脂是在非空腹状态下测定的，这可能会影响心血管风险评估。本研究的目的是评估新诊断的代谢综合征（MetSy）男性患者餐后低密度脂蛋白胆固醇（LDL-C）的变化。

方法

对36名男性患者进行了检查：12名患有MetSy的男性和24名未患MetSy的男性。在为期三个月的降血脂治疗前后进行了脂肪耐量试验。使用常规方法测量血脂，用比色法测量脂质过氧化物（LPO），用免疫比浊法测量载脂蛋白A-I、B和高敏C反应蛋白（hsCRP）。

结果

餐后甘油三酯的升高与LDL-C的降低和载脂蛋白B的小幅降低有关。在患有MetSy的男性中，LDL-C的平均变化（-19.5±2.3mg/dl）大于健康男性（-5.7±3.8mg/dl）。所有血脂变化（ΔTG、ΔLDL-C和ΔLPO）均与餐后非LDL胆固醇呈线性相关。经过三个月的降血脂治疗后，所有患有MetSy的男性的载脂蛋白B/载脂蛋白A-I比值与治疗前相同。