Skoczyńska Anna, Turczyn Barbara, Wojakowska Anna, Kreczyńska Bogusława, Skoczyńska Marta, Wojtas Kamila
Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wrocław, Poland, tel.: 71-7364005, fax: 71-7364009.
Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.
Open Med (Wars). 2015 Feb 3;10(1):138-151. doi: 10.1515/med-2015-0025. eCollection 2015.
In some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy).
36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apolipoproteins A-I, B, and hsCRP immunoturbidimetrically.
The postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-cholesterol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy.
In men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.
在一些流行病学研究中，血脂是在非空腹状态下测定的，这可能会影响心血管风险评估。本研究的目的是评估新诊断的代谢综合征（MetSy）男性患者餐后低密度脂蛋白胆固醇（LDL-C）的变化。
对36名男性患者进行了检查：12名患有MetSy的男性和24名未患MetSy的男性。在为期三个月的降血脂治疗前后进行了脂肪耐量试验。使用常规方法测量血脂，用比色法测量脂质过氧化物（LPO），用免疫比浊法测量载脂蛋白A-I、B和高敏C反应蛋白（hsCRP）。
餐后甘油三酯的升高与LDL-C的降低和载脂蛋白B的小幅降低有关。在患有MetSy的男性中，LDL-C的平均变化（-19.5±2.3mg/dl）大于健康男性（-5.7±3.8mg/dl）。所有血脂变化（ΔTG、ΔLDL-C和ΔLPO）均与餐后非LDL胆固醇呈线性相关。经过三个月的降血脂治疗后，所有患有MetSy的男性的载脂蛋白B/载脂蛋白A-I比值与治疗前相同。
在诊断为MetSy的男性中，餐后LDL胆固醇的降低可能会导致对心血管风险的低估。经过三个月的降血脂治疗后，这种风险仅部分降低，因为载脂蛋白B/载脂蛋白A-I比值保持不变。
