Department of Nutrition, The University of Tennessee, Knoxville, TN 37996-1920, USA.
Am J Clin Nutr. 2011 Aug;94(2):422-30. doi: 10.3945/ajcn.111.013342. Epub 2011 Jun 29.
Oxidative and inflammatory stress are elevated in obesity and are further augmented in metabolic syndrome. We showed previously that dairy components suppress the adipocyte- and macrophage-mediated generation of reactive oxygen species and inflammatory cytokines and systemic oxidative and inflammatory biomarkers in obesity.
The objective of this study was to determine the early (7 d) and sustained (4 and 12 wk) effects of adequate-dairy (AD) compared with low-dairy (LD) diets in subjects with metabolic syndrome.
Forty overweight and obese adults with metabolic syndrome were randomly assigned to receive AD (3.5 daily servings) or LD (<0.5 daily servings) weight-maintenance diets for 12 wk. Oxidative and inflammatory biomarkers were assessed at 0, 1, 4, and 12 wk as primary outcomes; body weight and composition were measured at 0, 4, and 12 wk as secondary outcomes.
AD decreased malondialdehyde and oxidized LDL at 7 d (35% and 11%, respectively; P < 0.01), with further decreases by 12 wk. Inflammatory markers were suppressed with intake of AD, with decreases in tumor necrosis factor-α at 7 d and further reductions through 12 wk (35%; P < 0.05); decreases in interleukin-6 (21%; P < 0.02) and monocyte chemoattractant protein 1 (14% decrease at 4 wk, 24% decrease at 12 wk; P < 0.05); and a corresponding 55% increase in adiponectin at 12 wk (P < 0.01). LD exerted no effect on oxidative or inflammatory markers. Diet had no effect on body weight; however, AD significantly reduced waist circumference and trunk fat (P < 0.01 for both), and LD exerted no effect.
An increase in dairy intake attenuates oxidative and inflammatory stress in metabolic syndrome. This trial was registered at clinicaltrials.gov as NCT01266330.
氧化应激和炎症应激在肥胖症中升高，在代谢综合征中进一步增加。我们之前表明，乳制品成分可抑制脂肪细胞和巨噬细胞介导的活性氧和炎性细胞因子的产生以及肥胖症中的系统性氧化和炎症生物标志物。
本研究的目的是确定代谢综合征患者中适量乳制品（AD）与低乳制品（LD）饮食的早期（7 天）和持续（4 和 12 周）作用。
40 名超重和肥胖的代谢综合征成年人被随机分配接受 AD（每天 3.5 份）或 LD（<0.5 份）维持体重的饮食 12 周。氧化和炎症生物标志物在 0、1、4 和 12 周时作为主要结果进行评估；体重和组成在 0、4 和 12 周时作为次要结果进行测量。
AD 在 7 天时降低了丙二醛和氧化型 LDL（分别为 35%和 11%；P<0.01），并在 12 周时进一步降低。随着 AD 的摄入，炎症标志物受到抑制，肿瘤坏死因子-α在 7 天时下降，12 周时进一步下降（35%；P<0.05）；白细胞介素-6（21%）和单核细胞趋化蛋白 1（4 周时降低 14%，12 周时降低 24%；P<0.05）；脂联素增加 55%（P<0.01）。LD 对氧化或炎症标志物没有影响。饮食对体重没有影响；然而，AD 显著减少了腰围和躯干脂肪（均为 P<0.01），而 LD 没有作用。
增加乳制品的摄入量可减轻代谢综合征中的氧化应激和炎症应激。本试验在 clinicaltrials.gov 上注册为 NCT01266330。
