Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China.
State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou 310058, Zhejiang, China.
Org Lett. 2017 Apr 7;19(7):1744-1747. doi: 10.1021/acs.orglett.7b00499. Epub 2017 Mar 29.
An iron(III)-promoted hydroalkynylation of unactivated alkenes toward Csp-Csp bond formation has been developed. Various alkenes, including mono-, di-, and trisubstituted alkenes, could all smoothly convert to structural diversified alkynes in this chemoselective protocol. Additionally, the scalability was unraveled and the further divergent transformations of products were conducted to demonstrate the synthetic utility.
一种铁(III)促进的未活化烯烃的氢炔丙基化反应，用于 Csp-Csp 键的形成，已经被开发出来。各种烯烃，包括单取代、二取代和三取代烯烃，都可以在这个化学选择性的方案中顺利转化为结构多样化的炔烃。此外，还揭示了可扩展性，并对产物进行了进一步的发散转化，以证明其合成实用性。
