Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China.
State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
Org Lett. 2018 Mar 2;20(5):1355-1358. doi: 10.1021/acs.orglett.8b00108. Epub 2018 Feb 19.
An Fe(III)-catalyzed hydroallylation of unactivated alkenes with Morita-Baylis-Hillman adducts via an Fe-catalyzed process is described. A variety of alkenes, including mono-, di-, and trisubstituted alkenes, could all smoothly convert to structural diversified cinnamates in this protocol. Interestingly, when the hydroxyl-containing alkenes were used, various lactones could be rapidly assembled. Moreover, this protocol could be applied to late-stage functionalization of natural products.
本文描述了一种通过铁催化过程实现的非活化烯烃与 Morita-Baylis-Hillman 加合物的 Fe(III)催化 hydroallylation。该方法可以实现各种烯烃的转化，包括单取代、二取代和三取代烯烃，得到结构多样化的肉桂酸酯。有趣的是，当使用含有羟基的烯烃时，各种内酯可以快速组装。此外，该方法还可以应用于天然产物的后期功能化。
