Kang Min-Gyu, Song Woo-Jung, Kim Hyun-Jung, Won Ha-Kyeong, Sohn Kyoung-Hee, Kang Sung-Yoon, Jo Eun-Jung, Kim Min-Hye, Kim Sae-Hoon, Kim Sang-Heon, Park Heung-Woo, Chang Yoon-Seok, Lee Byung-Jae, Morice Alyn H, Cho Sang-Heon
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine Department of Preventive Medicine, College of Medicine, Korea University, Seoul Department of Internal Medicine, Pusan National University College of Medicine, Busan Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam Department of Internal Medicine, Hanyang University College of Medicine Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Castle Hill Hospital, University of Hull, Cottingham, East Yorkshire, United Kingdom Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
Medicine (Baltimore). 2017 Mar;96(13):e6486. doi: 10.1097/MD.0000000000006486.
Cough is frequently self-limiting, but may persist longer in certain individuals. Most of previous studies on the epidemiology of chronic cough have only measured period prevalence, and thus have afforded limited information on the burden and natural course. We aimed to investigate the epidemiology of chronic cough by using a point prevalence measure in a large-scale general population.We analyzed cross-sectional data collected from 18,071 adults who participated in the Korean National Health and Nutrition Examination Survey 2010-2012. Presence and duration of current cough was ascertained by structured questionnaires, and cough was classified into acute (<3 weeks), subacute (3-8 weeks), or chronic cough (≥8 weeks). Demographic and clinical parameters were examined in relation to chronic cough.The point prevalences of acute, subacute, and chronic cough were 2.5 ± 0.2%, 0.8 ± 0.1% and 2.6 ± 0.2%, respectively. The proportion of current cough showed a steep decrease after 1 week of duration. However, 2 peaks in the prevalence of current cough were revealed; cough durations of less than 1 week and longer than 1 year were most common (31.1% and 27.7% of current cough, respectively). Subacute and chronic cough were more prevalent in the elderly (≥65 years); the positive associations with older age were independent of other confounders, including current smoking and comorbidities.This is the first report on the epidemiology of cough using a point prevalence measure in a nationally representative population sample. Our findings indicate a high burden of chronic cough among adults with current cough in the community. The dual-peak of cough duration suggested that the pathophysiology of acute and chronic cough may differ. The preponderance of elderly people in the prevalence of chronic cough warrants further investigation. In addition, more sophistication and validation of tools to define chronic cough will help our understanding of the epidemiology.
咳嗽通常具有自限性，但在某些个体中可能持续更长时间。以往大多数关于慢性咳嗽流行病学的研究仅测量了期间患病率，因此提供的关于负担和自然病程的信息有限。我们旨在通过在大规模普通人群中使用点患病率测量方法来调查慢性咳嗽的流行病学。我们分析了从参加2010 - 2012年韩国国民健康与营养检查调查的18071名成年人中收集的横断面数据。通过结构化问卷确定当前咳嗽的存在和持续时间，并将咳嗽分为急性（<3周）、亚急性（3 - 8周）或慢性咳嗽（≥8周）。检查了与慢性咳嗽相关的人口统计学和临床参数。急性、亚急性和慢性咳嗽的点患病率分别为2.5±0.2%、0.8±0.1%和2.6±0.2%。当前咳嗽的比例在持续1周后急剧下降。然而，发现当前咳嗽患病率有两个峰值；咳嗽持续时间少于1周和超过1年的情况最为常见（分别占当前咳嗽的31.1%和27.7%）。亚急性和慢性咳嗽在老年人（≥65岁）中更为普遍；与年龄较大的正相关独立于其他混杂因素，包括当前吸烟和合并症。这是第一份在具有全国代表性的人群样本中使用点患病率测量方法进行咳嗽流行病学研究的报告。我们的研究结果表明社区中患有当前咳嗽的成年人中慢性咳嗽负担较高。咳嗽持续时间的双峰表明急性和慢性咳嗽的病理生理学可能不同。慢性咳嗽患病率中老年人占优势值得进一步研究。此外，定义慢性咳嗽的工具更加精细和有效将有助于我们对流行病学的理解。
