Wang Yong-Tao, Tao Jing, Maimaiti Ailifeire, Adi Dilare, Yang Yi-Ning, Li Xiao-Mei, Ma Xiang, Liu Fen, Chen Bang-Dang, Ma Yi-Tong
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P. R. China.
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, P. R. China.
PLoS One. 2017 Mar 29;12(3):e0174490. doi: 10.1371/journal.pone.0174490. eCollection 2017.
Valvular heart diseases (VHD) is very common in clinical practice and has became the subject of growing attention in the field of cardiovascular medicine. Our aim was to assess the prevalence and correlates of VHD in the general population in Xinjiang, China.
Using a 4-stage stratified cluster random sampling method, a total of 14618 participants were recruited in the Cardiovascular Risk Survey (CRS) study. The participants' personal information, medical history were assessed by questionnaire. VHD was diagnosed by transthoracic echocardiography. We carried out the statistical analysis utilizing SPSS Statistics version 19.0.
In the total study group, VHD was observed in 1397 (9.65%) individuals. The prevalence rates of VHD in Han, Uygur and Kazak group are 13.51%, 2.71% and 12.29% respectively. The prevalence rates of VHD increased strikingly with age (all P < 0.001). The results of multinomial regression analysis indicated that VHD were related to age in Han group, to age smoking and hypertension in Uygur group, to age and hypertension in Kazak group.
Our research provides a unique prevalence rate of VHD in Xinjiang natural population. The result suggests that VHD are notably common in this population (9.65%) and increase with age. There exists significant difference of prevalence rate between ethnics. The main risk factors of VHD are age, hypertension and smoking. Valvular heart diseases should be regarded as a serious and growing public-health problem.
心脏瓣膜病（VHD）在临床实践中非常常见，已成为心血管医学领域日益受到关注的主题。我们的目的是评估中国新疆普通人群中VHD的患病率及其相关因素。
采用四阶段分层整群随机抽样方法，在心血管风险调查（CRS）研究中招募了总共14618名参与者。通过问卷调查评估参与者的个人信息、病史。通过经胸超声心动图诊断VHD。我们使用SPSS Statistics 19.0版本进行统计分析。
在整个研究组中，观察到1397名（9.65%）个体患有VHD。汉族、维吾尔族和哈萨克族组中VHD的患病率分别为13.51%、2.71%和12.29%。VHD的患病率随年龄显著增加（所有P<0.001）。多项回归分析结果表明，汉族组中VHD与年龄有关，维吾尔族组中与年龄、吸烟和高血压有关，哈萨克族组中与年龄和高血压有关。
我们的研究提供了新疆自然人群中VHD的独特患病率。结果表明，VHD在该人群中尤为常见（9.65%），且随年龄增加。不同民族之间患病率存在显著差异。VHD的主要危险因素是年龄、高血压和吸烟。心脏瓣膜病应被视为一个严重且日益严重的公共卫生问题。
