Reiniger J L, Domdei N, Pfau M, Müller P L, Holz F G, Harmening W M
Universitäts-Augenklinik Bonn, Universitätsklinikum Bonn.
Klin Monbl Augenheilkd. 2017 Mar;234(3):311-319. doi: 10.1055/s-0043-100631. Epub 2017 Mar 29.
The use of adaptive optics in ophthalmoscopy is a breakthrough technological achievement. With AO ophthalmoscopes, the microscopic retinal structure can be visualised non-invasively and on a cellular level, allowing for cellular scale imaging of the retinal nerve fibre layer, the smallest retinal capillaries, rod and cone photoreceptors, and the retinal pigment epithelium mosaic in the living subject. Regarding the diagnostic evaluation of retinal diseases, the current research focuses on monogenetic retinal diseases, which - when better understood - may allow for conclusions to be drawn about other multifactorial diseases and their underlying mechanisms (model disease). For disease monitoring and current and future pharmacological intervention (e.g. gene therapy), they will help to better establish novel and reliable clinical endpoints. New AO imaging devices have just become commercially available, and the number of retinal pathologies visualised with AO is increasing. Recently, an AO-based microstimulation technique has been introduced, which offers the possibility to directly correlate retinal structure with visual function on a cellular level.
眼科检查中自适应光学技术的应用是一项突破性的技术成就。借助自适应光学检眼镜，可以在细胞水平上对微观视网膜结构进行非侵入性可视化，从而在活体受试者中对视网膜神经纤维层、最小的视网膜毛细血管、视杆和视锥光感受器以及视网膜色素上皮镶嵌进行细胞尺度成像。关于视网膜疾病的诊断评估，当前的研究集中在单基因视网膜疾病上，一旦对其有更深入的了解，可能有助于推断其他多因素疾病及其潜在机制（模型疾病）。对于疾病监测以及当前和未来的药物干预（如基因治疗），它们将有助于更好地建立新的可靠临床终点。新型自适应光学成像设备刚刚上市，通过自适应光学技术可视化的视网膜病变数量正在增加。最近，一种基于自适应光学的微刺激技术被引入，它提供了在细胞水平上直接将视网膜结构与视觉功能相关联的可能性。
