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磁性纳米粒子:关于制备策略及其生物医学应用的综述

Magnetic Nanoparticles: A Review on Stratagems of Fabrication an d its Biomedical Applications.

作者信息

Srivastava Pratiksha, Sharma Pramod K, Muheem Abdul, Warsi Musarrat H

机构信息

School of Medical & Allied Sciences, Galgotias University, U.P. 201308, Greater Noida. India.

Faculty of Pharmacy, Hamdard University, Hamdard Nagar, 110062, New Delhi. India.

出版信息

Recent Pat Drug Deliv Formul. 2017;11(2):101-113. doi: 10.2174/1872211311666170328150747.

Abstract

BACKGROUND

The aim of this review is to provide an insight to the underlying biomedical applications of magnetic nanoparticles (MNPs).

METHODS

The most specific characteristic of MNPs is their response to an applied magnetic force, and this property of MNPs has been utilized in applications such as diagnosis of diseases, drug delivery and drug targeting. Currently, MNPs have attracted great attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heat mediators for cancer therapy (hyperthermia).

RESULTS

Furthermore, the MNPs are also being used to achieve targeted delivery of biological molecules. Nowadays cancer is one of the biggest challenges and our goal is not only to improve the therapeutic outcome, but also to improve the methods of treatment along with the minimum adverse effect. Some suitable conclusions have been quoted on the precise synthesis approaches by focusing the mechanism of MNPs and new modification made on the production of these nanoparticles.

CONCLUSION

In this review diverse biomedical application of MNPs were also addressed and patents related remarks also made from the literature.

摘要

背景

本综述旨在深入了解磁性纳米颗粒(MNPs)的潜在生物医学应用。

方法

MNPs最独特的特性是它们对施加的磁力的响应,MNPs的这一特性已被用于疾病诊断、药物递送和药物靶向等应用中。目前,MNPs因其作为磁共振成像(MRI)造影剂和癌症治疗(热疗)热介质的潜力而备受关注。

结果

此外,MNPs还被用于实现生物分子的靶向递送。如今癌症是最大的挑战之一,我们的目标不仅是提高治疗效果,还在于改进治疗方法并将副作用降至最低。通过聚焦MNPs的机制以及对这些纳米颗粒生产所做的新修饰,引用了一些关于精确合成方法的合适结论。

结论

本综述还探讨了MNPs在生物医学领域的多种应用,并从文献中给出了相关专利说明。

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