Mehrpooya Maryam, Eshraghi Azadeh, Rabiee Soghra, Larki-Harchegani Amir, Ataei Sara
Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan. Iran.
Department of Clinical Pharmacy, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran. Iran.
Rev Recent Clin Trials. 2017;12(3):148-153. doi: 10.2174/1574887112666170328125529.
Primary dysmenorrhea is common among young girls and childbearing women. Dysmenorrhea is a painful contraction of uterus which occurs in the beginning of bleeding or before the menstrual cycle begins. Regarding the mechanism of calcium in response to hormonal change and the role of fish oil on reducing prostaglandins, we compared the effectiveness of fish-oil and calcium supplementation in treating primary dysmenorrheal.
This randomized double-blinded clinical trial was conducted on women aged 18 to 45 years with moderate to severe primary dysmenorrhea symptoms from January 2015 to March 2015. The women were randomly divided to two groups (fish oil and calcium). The drugs were given every day in the first cycle and from 8 days before till 2 days after initiation of menstruation for the second and third cycles. The intensity of pain and other symptoms of dysmenorreha were recorded and data were analyzed in SPSS 16 using T-test and X2 tests. Significant level was considered to be less than 0.05.
The mean ± SD age of the patients in the fish oil group was 25.0±4.3 and in calcium group was 25.48±6.6 years. According to this result, there was no statistically significant difference in the intensity of pain between fish-oil group and calcium group before and 1 month after the study (P>0.05). However, there was statistically significant difference between fish-oil group and calcium group before the study and 2 months (P=0.001) and 3 months after study (p<0.001). Besides, the fishoil patients needed less analgesic as compared to the calcium patients.
It is concluded that omega-3 is more effective than calcium, what can be justified by pain mechanisms and symptoms pathology in dysmenorrheal.
原发性痛经在年轻女孩和育龄妇女中很常见。痛经是子宫的一种疼痛性收缩，发生在出血开始时或月经周期开始之前。关于钙对激素变化的反应机制以及鱼油在减少前列腺素方面的作用，我们比较了鱼油和补钙在治疗原发性痛经方面的效果。
这项随机双盲临床试验于2015年1月至2015年3月对年龄在18至45岁、有中度至重度原发性痛经症状的女性进行。这些女性被随机分为两组（鱼油组和钙组）。药物在第一个周期每天服用，在第二个和第三个周期从月经开始前8天至月经开始后2天服用。记录痛经的疼痛强度和其他症状，并在SPSS 16中使用t检验和卡方检验分析数据。显著性水平被认为小于0.05。
鱼油组患者的平均年龄±标准差为25.0±4.3岁，钙组为25.48±6.6岁。根据这一结果，鱼油组和钙组在研究前和研究后1个月的疼痛强度没有统计学上的显著差异（P>0.05）。然而，鱼油组和钙组在研究前与研究后2个月（P=0.001）和3个月（P<0.001）存在统计学上的显著差异。此外，与钙组患者相比，鱼油组患者需要的镇痛药更少。
得出的结论是，ω-3比钙更有效，这可以通过痛经的疼痛机制和症状病理学来解释。
