Adjibade Moufidath, Andreeva Valentina A, Lemogne Cédric, Touvier Mathilde, Shivappa Nitin, Hébert James R, Wirth Michael D, Hercberg Serge, Galan Pilar, Julia Chantal, Assmann Karen E, Kesse-Guyot Emmanuelle
Paris 13 University, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory of Arts and Crafts (CNAM), Sorbonne Paris Cité COMUE, Bobigny, France;
Paris 13 University, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory of Arts and Crafts (CNAM), Sorbonne Paris Cité COMUE, Bobigny, France.
J Nutr. 2017 May;147(5):879-887. doi: 10.3945/jn.116.245167. Epub 2017 Mar 29.
Low-grade chronic inflammation, which can be modulated by diet, has been suggested as an important risk factor for depression, but few studies have investigated the association between the inflammatory potential of the diet and depression. We investigated the prospective association between the inflammatory potential of the diet, measured by the Dietary Inflammatory Index (DII), and incident depressive symptoms and tested the potential modulating effect of sex, age, physical activity, and smoking status. This study included 3523 participants (aged 35-60 y) from the SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) cohort, who were initially free of depressive symptoms. Baseline DII (1994-1996) was computed by using repeated 24-h dietary records. Incident depressive symptoms were defined by a Center for Epidemiologic Studies-Depression Scale score ≥17 for men and ≥23 for women in 2007-2009. We used multivariable logistic regression models to estimate ORs and 95% CIs, and modeled the DII as a continuous variable and as sex-specific quartiles. A total of 172 cases of incident depressive symptoms were identified over a mean follow-up of 12.6 y. The DII was not associated with incident depressive symptoms in the full sample. In sex-specific models, men with a higher DII had a higher risk of incident depressive symptoms (quartile 4 compared with quartile 1-OR: 2.32; 95% CI: 1.01, 5.35), but the association was only marginally significant (-trend = 0.06). When analyses were performed across smoking status, current and former smokers with a higher DII had a higher risk of incident depressive symptoms (quartile 4 compared with quartile 1-OR: 2.21; 95% CI: 1.08, 4.52). A positive association was also observed among less physically active participants (quartile 4 compared with quartile 1-OR: 2.07; 95% CI: 1.05, 4.07). The promotion of a healthy diet with anti-inflammatory properties may help to prevent depressive symptoms, particularly among men, smokers, or physically inactive individuals. This trial was registered at clinicaltrials.gov as NCT0027242.
低度慢性炎症可通过饮食调节，已被认为是抑郁症的一个重要风险因素，但很少有研究调查饮食的炎症潜能与抑郁症之间的关联。我们通过饮食炎症指数（DII）测量饮食的炎症潜能，并研究其与新发抑郁症状之间的前瞻性关联，同时检验性别、年龄、身体活动和吸烟状况的潜在调节作用。本研究纳入了来自SU.VI.MAX（抗氧化维生素和矿物质补充剂）队列的3523名参与者（年龄在35至60岁之间），这些参与者最初无抑郁症状。通过重复的24小时饮食记录计算基线DII（1994 - 1996年）。新发抑郁症状定义为2007 - 2009年男性流行病学研究中心抑郁量表评分≥17分，女性≥23分。我们使用多变量逻辑回归模型来估计比值比（OR）和95%置信区间（CI），并将DII建模为连续变量以及按性别划分的四分位数。在平均12.6年的随访期间，共识别出172例新发抑郁症状病例。在整个样本中，DII与新发抑郁症状无关联。在按性别分层的模型中，DII较高的男性出现新发抑郁症状的风险更高（四分位数4与四分位数1相比 - OR：2.32；95% CI：1.01，5.35），但该关联仅具有边缘显著性（-趋势 = 0.06）。在按吸烟状况进行分析时，DII较高的当前吸烟者和既往吸烟者出现新发抑郁症状的风险更高（四分位数4与四分位数1相比 - OR：2.21；95% CI：1.08，4.52）。在身体活动较少的参与者中也观察到正相关（四分位数4与四分位数1相比 - OR：2.07；95% CI：1.05，4.07）。推广具有抗炎特性的健康饮食可能有助于预防抑郁症状，特别是在男性、吸烟者或身体活动不足的个体中。该试验已在clinicaltrials.gov注册，注册号为NCT0027242。
