Mariani F, Boarino V, Bertani A, Merighi A, Pedroni M, Rossi G, Mancini S, Sena P, Benatti P, Roncucci L
Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
Department of Medicine, Emergency Medicine and Medical Specialties, Endoscopy Unit, Policlinico, Modena, Italy.
Int J Obes (Lond). 2017 Jun;41(6):982-985. doi: 10.1038/ijo.2017.80. Epub 2017 Mar 30.
Body fatness is a risk factor for colorectal cancer, and promotes an inflammatory environment. Indeed, inflammation in normal colorectal mucosa may be a factor linking body fatness to colorectal carcinogenesis. In this study, we evaluated myeloperoxidase (MPO)-positive cells infiltration of normal colorectal mucosa as a marker of cancer-promoting inflammation in overweight and obese subjects. One hundred and three subjects with normal colonoscopy entered the study. Waist circumference (WC) and body mass index (BMI) were measured, and MPO-positive cells on histological sections of biopsies of normal colorectal mucosa were counted under a light microscope. The occurrence of adenomas was then evaluated on follow-up colonoscopies. Mean MPO-positive cell count (±s.e.m.) was higher in subject with a WC equal or above the obesity cutoff values according to gender (2.63±0.20 vs 2.06±0.18, P=0.03), and in subjects with BMI equal or above 25 kg m (2.54±0.18 vs 1.97±0.20, P=0.03). A Cox proportional hazard model showed that mean MPO-positive cell count in normal colorectal mucosa was the only factor independently related to occurrence of adenomas in follow-up colonoscopies. Though preliminary, these results show that MPO-positive cell infiltration in normal colorectal mucosa is related with body fatness, as evaluated by WC and BMI, and it may be considered a useful and simple marker to estimate adenoma occurrence risk.
体脂是结直肠癌的一个风险因素，并会促进炎症环境的形成。事实上，正常结直肠黏膜中的炎症可能是将体脂与结直肠癌发生联系起来的一个因素。在本研究中，我们评估了超重和肥胖受试者正常结直肠黏膜中髓过氧化物酶（MPO）阳性细胞浸润情况，将其作为促癌炎症的一个标志物。103名结肠镜检查正常的受试者进入了该研究。测量了腰围（WC）和体重指数（BMI），并在光学显微镜下对正常结直肠黏膜活检组织切片上的MPO阳性细胞进行计数。然后在后续的结肠镜检查中评估腺瘤的发生情况。根据性别，腰围等于或高于肥胖临界值的受试者的平均MPO阳性细胞计数（±标准误）更高（2.63±0.20对2.06±0.18，P = 0.03），BMI等于或高于25 kg/m²的受试者也是如此（2.54±0.18对1.97±0.20，P = 0.03）。Cox比例风险模型显示，正常结直肠黏膜中的平均MPO阳性细胞计数是与后续结肠镜检查中腺瘤发生独立相关的唯一因素。尽管这些结果是初步的，但它们表明，通过腰围和体重指数评估，正常结直肠黏膜中的MPO阳性细胞浸润与体脂有关，并且它可能被认为是一种有用且简单的标志物，用于估计腺瘤发生风险。
