Dhanapriya J, Dineshkumar T, Sakthirajan R, Murugan S, Jayaprakash V, Balasubramaniyan T, Gopalakrishnan N
Department of Nephrology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.
Indian J Nephrol. 2017 Mar-Apr;27(2):151-153. doi: 10.4103/0971-4065.181883.
Scrub typhus is a rickettsial infection commonly seen in Asia. The clinical presentation ranges from nonspecific febrile illness to potentially fatal multiorgan involvement such as liver, kidney, or lung. Central nervous system involvement is uncommon. We report a 45-year-old female renal transplant recipient who presented with fever, headache, meningeal signs, graft dysfunction, and eschar. IgM antibodies against were positive by enzyme-linked immunosorbent assay. Despite oral doxycycline therapy for 5 days, she did not improve but responded well to intravenous azithromycin. To the best of our knowledge, scrub typhus as a cause of meningitis in a renal transplant recipient has not been reported so far.
恙虫病是一种常见于亚洲的立克次体感染。临床表现从非特异性发热疾病到可能致命的多器官受累,如肝脏、肾脏或肺部。中枢神经系统受累并不常见。我们报告了一名45岁的女性肾移植受者,她出现发热、头痛、脑膜刺激征、移植肾功能障碍和焦痂。酶联免疫吸附试验显示抗[具体病原体]的IgM抗体呈阳性。尽管口服强力霉素治疗5天,但她并无改善,而静脉注射阿奇霉素后反应良好。据我们所知,恙虫病作为肾移植受者脑膜炎的病因迄今尚未见报道。