Pak Jaewoo, Lee Jung Hun, Park Kwang Seung, Jeon Jeong Ho, Lee Sang Hee
Stems Medical Clinic, Gangnamgu, Seoul, Republic of Korea; TEDA-Puhua International Hospital, Tianjin, People's Republic of China; Life Science Institute, Komplek Permata Senayan, Jalan Tentara Pelajar, Jakarta Selatan, Indonesia.
Stems Medical Clinic, Gangnamgu, Seoul, Republic of Korea; National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
Open Access J Sports Med. 2017 Mar 23;8:33-38. doi: 10.2147/OAJSM.S113018. eCollection 2017.
The menisci of the human knee play an important role in maintaining normal functions to provide stability and nutrition to the articular cartilage, and to absorb shock. Once injured, these important structures have very limited natural healing potential. Unfortunately, the traditional arthroscopic meniscectomy performed on these damaged menisci may predispose the joint toward early development of osteoarthritis. Although a very limited number of studies are available, mesenchymal stem cells (MSCs) have been investigated as an alternative therapeutic modality to repair human knee meniscal tears. This review summarizes the results of published applications of MSCs in human patients, which showed that the patients who received MSCs (autologous adipose tissue-derived stem cells or culture-expanded bone marrow-derived stem cells) presented symptomatic improvements, along with magnetic resonance imaging evidences of the meniscal repair.
人类膝关节半月板在维持正常功能方面发挥着重要作用，为关节软骨提供稳定性和营养，并吸收冲击。一旦受损，这些重要结构的自然愈合潜力非常有限。不幸的是，对这些受损半月板进行的传统关节镜半月板切除术可能会使关节更容易早期发展为骨关节炎。尽管可用的研究数量非常有限，但间充质干细胞（MSCs）已被研究作为修复人类膝关节半月板撕裂的替代治疗方式。本综述总结了已发表的MSCs在人类患者中的应用结果，结果显示接受MSCs（自体脂肪组织来源的干细胞或培养扩增的骨髓来源的干细胞）的患者症状有所改善，同时磁共振成像显示半月板有修复迹象。
